Review Details Brain Organoid Progress in Disease Modeling and Key Challenges
A scientific review details advancements in stem cell-derived brain organoids for disease modeling and drug screening alongside critical challenges in ...
Tag: brain organoids
Human brain organoids reveal genetic switches that set us apart from great apes
Lab-grown brain organoids from humans, chimpanzees and gorillas reveal nearly 600 genetic switches that are more active in human neural ...
Human Brain Organoids Transform Laboratory Models of Neurological Development and Disease
A comprehensive review examines how stem cell-derived three-dimensional brain organoids and assembloids are reshaping research into human neurodevelopment, circuit assembly, ...
Scientists map a million cells revealing the predictable rules of glioblastoma
A single-cell and spatial atlas of 12 glioblastoma tumours shows that cancer cells progress through the same ordered sequence of ...
From PTZ to Brain Organoids: How Scientists Choose the Right Epilepsy Model
A new review maps how chemical, electrical, genetic, acquired, and in vitro epilepsy models each capture distinct mechanisms of epileptogenesis, ...
Organoids Reveal Interneuron Defects Drive Genetic Focal Epilepsy
Patient-derived ventral organoids show that GATOR1-related focal epilepsy involves MAFB-driven interneuron defects independent of mTOR hyperactivation.
Brain Organoids Offer a Human Window on Stroke, but Fetal-Like Cells and Missing Immunity Still Limit the Models
A new narrative review argues that human brain organoids are reshaping stroke research by exposing human-specific injury mechanisms that animal ...
Patient-derived stem cells and organoids open a new window on Moyamoya disease
A new review maps how patient-derived induced pluripotent stem cells and three-dimensional vascular and neurovascular organoids are transforming Moyamoya disease ...
Lab-Grown Brain Tissue Learns to Read Braille in Bio-Hybrid Computing Breakthrough
Researchers at the University of Bristol have demonstrated that human brain organoids can classify all 26 Braille letters with 83 ...
New Protocol Keeps Living Brain Slices Alive for Weeks to Track Birth of New Neurons
Researchers have refined a decades-old method for keeping intact mouse hippocampal slices alive for weeks, enabling precise quantification of newborn ...
Brain organoids without immune cells may miss the real story of neurodegeneration
A PLOS Biology Perspective argues that immune and vascular cells, especially microglia, must be core components of neural organoids used ...
Massive Cell-by-Cell Map Reveals the Cerebellum’s Hidden Role in Alzheimer’s Disease
A single-nucleus multiome atlas of over 100,000 brain cells reveals disease-linked regulatory programs and potentially causal genetic variants in the ...
From Dish to Living Brain: How Lab-Grown Human Microglia Are Rewriting Neuroimmune Research
A new review charts how stem cell-derived human microglia, brain organoids and chimeric mice are overcoming the genetic and environmental ...
Multifocal Metalens Enables Sub-Diffraction Brain Imaging
In a groundbreaking advancement at the intersection of photonics and biological imaging, researchers have successfully leveraged a novel multifocal metalens-based ...
Advancements in Graphene Technology Accelerate Maturation of Brain Organoids, Paving the Way for Insights into Neurodegenerative Diseases
Researchers at the University of California San Diego’s Sanford Stem Cell Institute have made a groundbreaking advancement in neuroscience by ...
