Tag: Blood-brain barrier

University of Ottawa researchers report that extracellular vesicles can ferry engineered antibodies across the blood-brain barrier, and that tagging disease ...

A study of people with HIV-1 and cryptococcal meningitis reveals diverse mechanisms shaping viral populations in the central nervous system, ...

A new review reveals that synaptic failure—not plaque burden—is the strongest driver of Alzheimer's cognitive decline, and plant-derived phytochemicals may ...

A new review from Yale University traces how peripheral immune signals reach the prefrontal, insular, and somatosensory cortices through neural ...

A new review of preclinical evidence shows that precision-engineered nanocarriers, from platelet-hitchhiking cancer drugs to brain-penetrating siRNA particles, are transforming ...

A systematic review and meta-analysis of 23 studies and 547 patients finds that CD19-directed CAR T-cell therapy delivers encouraging one-year ...

Researchers propose that autonomic nervous system disequilibrium after aneurysmal subarachnoid hemorrhage may amplify blood–brain barrier breakdown and drive vasogenic cerebral ...

A new hypothesis-driven framework proposes that metabolic syndrome may prime the brain's immune cells through trained-immunity-like mechanisms and weaken parvalbumin ...

A multi-cohort transcriptomic, genetic, and experimental study identifies the RHBDF2–ADAM17–TNFα axis as a molecular bridge linking ulcerative colitis to blood–brain ...

A case report in the Journal of Neurology documents systemic and central nervous system hypofucosylation in a child with GLUT1 ...

A new review argues that gut-derived short-chain fatty acids, especially butyrate, could protect newborn brains from hypoxic-ischemic injury by breaking ...

A new integrative review argues that exercise-related brain remodeling emerges from bidirectional brain-body crosstalk rather than a single peripheral factor, ...

A new review in Biogerontology argues that the Hippo–YAP/TAZ signalling pathway acts as a central hub linking brain ageing, neurodegeneration, ...

A new review maps how the peptide hormone adropin, once seen as a simple metabolic signal, orchestrates vascular, neurological, fibrotic, ...

A single-vessel analysis of human brain tissue shows that pericyte loss and endothelial activation are partially dissociated processes defining three ...

Chronic inhibition of the enzyme soluble epoxide hydrolase with TPPU restored memory, cerebral blood flow, blood-brain barrier integrity, and neuronal ...

A retrospective study of 25 patients suggests that adding the anti-PD-1 antibody pucotenlimab to concurrent radiochemotherapy produced tumor responses and ...

A new review proposes the Iron-Brain Nexus framework to explain why the brain is uniquely vulnerable to iron-dependent ferroptotic cell ...

Mount Sinai and Johnson & Johnson will collaboratively evaluate an investigational liquid radioembolic that combines Iodine-131 with TRUFILL n-BCA to ...

A computational study identifies plant-derived compounds, notably coumarin, as promising dual inhibitors of the ROCK1 and ROCK2 enzymes that regulate ...