Tag: Blood-brain barrier

In a prospective, multicenter, single-arm phase II trial conducted at four centers in China, orelabrutinib plus R-CDOP was associated with ...

An experimental mouse and cell study found that the adamantane-nitrone hybrid TA1 reduced cerebral infarct volume from 32.97% to 14.33% ...

An L-alanine-functionalized, virus-like mesoporous silica carrier improved antibiotic delivery and therapeutic outcomes in mouse models of bacterial meningitis.

A 2026 review finds that natural products affect multiple neuroprotective and repair pathways in vascular dementia models, but mostly preclinical ...

A computational screen followed by cell-free Aβ42 assays identified four Jowiseungchungtang-derived small molecules that inhibited aggregation, with two also reducing ...

A new review details how extracellular vesicles carrying brain-derived proteins and RNAs could enable minimally invasive diagnosis of Alzheimer's, Parkinson's, ...

A review of 11 validated studies shows how ultra-sensitive analysis is reshaping efforts to measure rivastigmine, a rapidly cleared brain-targeted ...

A new review proposes that age-related remodeling of the sugar layer lining brain blood vessels could converge with galectin-3 inflammatory ...

A new conceptual framework called the Gut-Brain Homeostatic Continuum reframes Alzheimer's disease as a progressive erosion of organismal resilience driven ...

A prospective study finds that dynamic contrast-enhanced MRI detects significant vascular changes in brain metastases within four to eight weeks ...

A new review in Molecular Biology Reports details how the dietary flavonoid apigenin combats oxidative stress, neuroinflammation, mitochondrial dysfunction, and ...

A new review argues that the ubiquitin-proteasome system degrades P-glycoprotein at the blood-brain barrier, impairing amyloid-beta clearance and offering new ...

A new Oncoscience perspective maps the 2025–2026 glioblastoma clinical trial pipeline across four mechanistic domains, showing how biomarker-guided selection and ...

A new review in Pharmacia charts how magnetic nanoparticles, metal-organic frameworks, and ROS-responsive carriers are transforming targeted cancer therapy and ...

A new review argues that the bottleneck for RNAi therapies in Alzheimer's, Parkinson's and Huntington's disease is not gene silencing ...

A new review argues that recurrent mitochondrial metabolic stress, redox imbalance, and inflammatory signaling converge on the neurovascular unit to ...

A new perspective in Frontiers in Molecular Neuroscience argues that chronic circadian misalignment should be reconceptualized as a potential, modifiable ...

A neuroimaging study of 211 adults found that people with metabolic syndrome have larger choroid plexus volumes linked to low ...

A biomimetic nanoplatform cloaked in microglial cell membranes delivers carbon monoxide, manganese ions, and Gasdermin E across the blood-brain barrier ...

A new narrative review argues that ApoE4 acts as a context-dependent susceptibility modifier in cerebral small vessel disease rather than ...