Blood Pressure Drug Model L-NAME Directly Pushes Vascular Smooth Muscle Cells Toward Foam Cell State
A new in vitro study reports that the NOS inhibitor L-NAME directly induces lipid accumulation and synthetic phenotype marker changes ...
Tag: Atherosclerosis
How far atherosclerosis spreads in neck and head arteries mirrors coronary disease burden in NSTEACS patients
A single-center cross-sectional study of 186 NSTEACS patients found that the extent of cervicocephalic atherosclerosis, rather than its severity, was ...
Metabolic Syndrome Severity Score Tracks With Coronary Artery Complexity in New Study
A retrospective cross-sectional study of 156 patients found that higher metabolic syndrome severity Z-scores were associated with more complex coronary ...
Endothelial protein CCDC92 found to restrain early atherosclerosis through STAT1 degradation
A new study reports that the endothelial protein CCDC92 promotes STAT1 degradation through the proteasome and that its loss, linked ...
Type 2 diabetes linked to nearly a decade of extra coronary artery aging on CT scans
A retrospective study of 4,211 people undergoing coronary CT angiography found that type 2 diabetes was independently associated with more ...
Cardiovascular disease remains a major burden for people with type 1 diabetes
A new review finds cardiovascular disease remains a major cause of morbidity and mortality in type 1 diabetes, with dedicated ...
APOE ε4 Carriers Face Higher Heart Attack Risk, Large Genetic Review Finds
A new meta-analysis of 36 case-control studies links the APOE ε4 allele to increased heart attack risk, with the strongest ...
Same Receptor, Opposite Fates: Why S1PR1 Cuts Both Ways in Atherosclerosis
A new review argues that the atherogenic outcome of S1PR1 signalling depends on cell type, ligand presentation and inflammatory context ...
Ancient Chinese Formula Sini Decoction Rewires Immune Cells in Lab Study of Atherosclerosis
A cell study reports that Sini Decoction-containing serum dose-dependently shifted LPS-stimulated macrophages toward an anti-inflammatory state and upregulated NCOR1, though ...
Radial artery calcification found in 13 percent of transradial PCI patients
A retrospective OCT study of 461 patients found radial artery calcification in 13.2 percent, most often in the distal segment, ...
Same Drug, Different Cells: Why mTOR Inhibition in Plaques Defies Simple Rules
A new review argues that mTOR's effects in atherosclerotic plaques depend on cell state, plaque niche, signalling complex and drug ...
DDIT4 protein worsens artery narrowing by disrupting smooth muscle cell metabolism
A Nature Communications study shows that the protein DDIT4 drives vascular smooth muscle cell switching and artery thickening in mice ...
Late-life blood pressure decline signals brain vessel damage in women
An autopsy study of 2,033 older adults links faster late-life systolic blood pressure decline to more severe brain arteriolosclerosis and ...
Experimental drug rejuvenates aged rat livers, halving amyloid beta and LDL
In aged rats, the experimental drug cinaciguat restored aging liver sieve cells, cutting blood amyloid beta in half and lowering ...
Chemical Tags on RNA May Steer the Course of Aortic Dissection
A new review details how the RNA modification m6A influences cell death, inflammation and risk factors in aortic dissection, pointing ...
Plaque Transcriptomics Point to BCAP31 as a Stress Buffer in Carotid Atherosclerosis
An integrated analysis of human carotid plaque transcriptomes and macrophage experiments suggests that elevated BCAP31 in atherosclerotic lesions may reflect ...
Framework Separates DNA-Sensing Claims by Cell Type and Disease Stage
A focused review finds that cGAS–STING and AIM2 claims in atherosclerosis depend on the DNA source, cellular lineage, disease stage ...
Computer model finds timing and dose govern simulated endothelial repair
A multiscale simulation found that endothelial repair depended on early, moderate AKT activation and on balancing local nitric oxide production ...
Carotid Geometry Links to Stenosis and Disturbed Blood Flow
A cross-sectional MRI and computational fluid dynamics study links carotid geometry to both arterial stenosis and potentially pro-atherogenic flow patterns, ...
Protein Clues Reveal Why Heart Risk Lingers After Bad Cholesterol Falls
A large Swedish proteomics study of nearly 3,000 blood proteins in 35,000 UK Biobank participants reveals how triglyceride-rich lipoproteins and ...
