3D Tumor Models Expose How Biliary Tract Cancers Evade Chemotherapy
A new review argues that three-dimensional tumor models, including patient-derived organoids, can reveal the drug resistance and apoptosis evasion mechanisms ...
Tag: Apoptosis
Tiny Protein G0S2 Emerges as a Master Switch for Cell Death in Liver Cancer
A new proteomic study reports that the small protein G0S2 promotes apoptosis through the BAX/Caspase3 pathway, positioning it as a ...
RNA-Binding Protein HuR Emerges as a Master Switch in Tau Splicing and Alzheimer’s Genes
A new study identifies the RNA-binding protein HuR as a repressor of tau exon 10 splicing and a regulator of ...
Disc Degeneration Traced to a Histone Switch That Silences the Cell’s Mitochondrial Cleanup Crew
A new study shows that the chromatin protein CBX3 accelerates disc degeneration by silencing the SESN2 gene through H3K9me3 marks, ...
Black Wattle Tree Extract Shows Potent Anticancer Activity Against Bladder Cancer Cells
Brazilian researchers report that proanthocyanidins from black wattle bark kill bladder cancer T24 cells at low concentrations and modulate cancer-related ...
Zinc-Locked Herbal Hydrogel Attacks Tumors and Their Blood Supply at Once
Researchers have created a zinc-crosslinked rhein and pectin hydrogel that gels inside tumors, arresting melanoma cells in the G2/M phase ...
Spirulina pigment dismantles a key shield that blocks breast cancer drug response
A new cell study shows that C-phycocyanin can strip away Mcl-1-driven resistance and make the BH3-mimetic ABT-737 far more lethal ...
Hepatitis B Virus X Protein Mutation T118N Reshapes Cell Cycle and Apoptosis in Liver Cells
New research shows that the hepatitis B virus X protein T118N mutation, common in Indonesia, increases Cyclin E expression and ...
AI Reads Live Cell Videos to Predict Cancer Cell Fates Before They Happen
A Transformer deep learning model predicts cancer cell fates directly from live-cell videos with high accuracy up to eight hours ...
Silencing a Fat-Making Master Switch Pushes Pancreatic Cancer Cells Toward Self-Destruction
New research links elevated SREBF1 expression to lipid metabolism signatures in pancreatic cancer and shows that silencing the gene triggers ...
Scientists Identify HERC4 as the Molecular Switch That Turns TNF Survival Signals Into Cell Death
Researchers have discovered that the protein HERC4 acts as the critical molecular switch that converts TNF survival signalling into cell ...
Virus-driven lymphoma cells rely on a mitochondrial enzyme duo to dodge cell death
New research reveals that the mitochondrial ubiquitin ligase MARCHF5 helps KSHV-transformed lymphoma cells survive by degrading NOXA, the natural antagonist ...
Resveratrol Shields the Epileptic Brain by Rewiring Ion Channel Genes, Rat Study Finds
A new rat study shows that resveratrol slows epilepsy development and protects the hippocampus by restoring SIRT1 signaling and rebalancing ...
Nanoparticle Citrus Flavonoid Shields Kidneys in Mice with Cancer, Study Finds
A new study in Medical Oncology reports that diosmin loaded into chitosan nanoparticles reduced tumor burden and protected the kidneys ...
Ginger Compound Zerumbone Halts Growth of Aggressive Uterine Cancer Cells in Lab Study
A new in vitro study reports that zerumbone, a sesquiterpene from wild ginger, arrests SK-UT-1 uterine leiomyosarcoma cells in the ...
Rare Sugar D-Allose Rewires a Mitochondrial Stress Circuit to Slow Disc Degeneration
A new study shows that the rare sugar D-allose restores mitophagy, suppresses cGAS–STING signalling and preserves the cytoprotective peptide ADM2 ...
Gallic Acid Shrinks Tumors in Mice While Sparing Blood Cells, Study Finds
A new preclinical study shows that orally delivered gallic acid significantly inhibited sarcoma tumor growth in mice by suppressing proliferation, ...
Silencing PD-L1 Reveals a Hidden Phosphatase Axis That May Drive Gastric Cancer Survival
New research shows that silencing the PD-L1 gene in gastric cancer cells reshapes the expression of MAPK-regulating DUSP phosphatases, revealing ...
Stem Cells Rescue Damaged Ovaries by Silencing a Cell Death Program, Mouse Study Shows
A new mouse study shows that bone marrow mesenchymal stem cells treat chemotherapy-induced premature ovarian failure by rebalancing the Bcl2/Caspase3 ...
Fruit Fly Protein Xrp1 Guards the Genome Through Two Separate Tumor-Suppressing Pathways
A new PLOS Genetics study shows that the Drosophila protein Xrp1 protects genome integrity through both a p53-dependent DNA damage ...
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