Silencing a Fat-Making Master Switch Pushes Pancreatic Cancer Cells Toward Self-Destruction
New research links elevated SREBF1 expression to lipid metabolism signatures in pancreatic cancer and shows that silencing the gene triggers ...
Tag: Apoptosis
Scientists Identify HERC4 as the Molecular Switch That Turns TNF Survival Signals Into Cell Death
Researchers have discovered that the protein HERC4 acts as the critical molecular switch that converts TNF survival signalling into cell ...
Virus-driven lymphoma cells rely on a mitochondrial enzyme duo to dodge cell death
New research reveals that the mitochondrial ubiquitin ligase MARCHF5 helps KSHV-transformed lymphoma cells survive by degrading NOXA, the natural antagonist ...
Resveratrol Shields the Epileptic Brain by Rewiring Ion Channel Genes, Rat Study Finds
A new rat study shows that resveratrol slows epilepsy development and protects the hippocampus by restoring SIRT1 signaling and rebalancing ...
Nanoparticle Citrus Flavonoid Shields Kidneys in Mice with Cancer, Study Finds
A new study in Medical Oncology reports that diosmin loaded into chitosan nanoparticles reduced tumor burden and protected the kidneys ...
Ginger Compound Zerumbone Halts Growth of Aggressive Uterine Cancer Cells in Lab Study
A new in vitro study reports that zerumbone, a sesquiterpene from wild ginger, arrests SK-UT-1 uterine leiomyosarcoma cells in the ...
Rare Sugar D-Allose Rewires a Mitochondrial Stress Circuit to Slow Disc Degeneration
A new study shows that the rare sugar D-allose restores mitophagy, suppresses cGAS–STING signalling and preserves the cytoprotective peptide ADM2 ...
Gallic Acid Shrinks Tumors in Mice While Sparing Blood Cells, Study Finds
A new preclinical study shows that orally delivered gallic acid significantly inhibited sarcoma tumor growth in mice by suppressing proliferation, ...
Silencing PD-L1 Reveals a Hidden Phosphatase Axis That May Drive Gastric Cancer Survival
New research shows that silencing the PD-L1 gene in gastric cancer cells reshapes the expression of MAPK-regulating DUSP phosphatases, revealing ...
Stem Cells Rescue Damaged Ovaries by Silencing a Cell Death Program, Mouse Study Shows
A new mouse study shows that bone marrow mesenchymal stem cells treat chemotherapy-induced premature ovarian failure by rebalancing the Bcl2/Caspase3 ...
Fruit Fly Protein Xrp1 Guards the Genome Through Two Separate Tumor-Suppressing Pathways
A new PLOS Genetics study shows that the Drosophila protein Xrp1 protects genome integrity through both a p53-dependent DNA damage ...
Turmeric Compound and Black Pepper Molecule Team Up to Block Liver Cancer in Rats
A new rat study in BMC Cancer reports that curcumin and piperine, especially in combination, prevent chemically induced hepatocellular carcinoma ...
Curcumin Shows Promise Against Ovarian Cancer, but Nanotechnology May Hold the Key
A systematic review of 21 preclinical studies finds that curcumin and its nanoformulations modulate key cancer signaling pathways and enhance ...
Experimental Drug SMIP004 Hunts Down Dormant Cancer Cells Left Behind by Chemotherapy
Researchers report that the mitochondria-targeting compound SMIP004 selectively kills therapy-induced senescent cancer cells by promoting degradation of the AMPK-stabilized metabolic ...
Triaptosis: Scientists Unveil a New Form of Cell Death Centered on Endosomes
A new review in Cell Death & Discovery proposes triaptosis, an endosome-centered form of ROS-regulated cell death driven by oxidative ...
Old Antipsychotic Meets Mitochondrial Blocker in Two-Drug Strike on Cancer Cells
New research shows that pairing the decades-old antipsychotic chlorpromazine with the mitochondrial fission inhibitor mdivi-1 sharply boosts cancer cell death ...
Fatty Liver Cells Turn On a Caspase-2 Death Pathway That Damps Hepatitis B Replication
New in vitro research shows that free fatty acid–induced steatosis activates a TNF-α/TNFR1–Caspase−8/Caspase−2 apoptotic pathway that is associated with reduced ...
Scientists map the developing human heart cell by cell and reveal how Down syndrome disrupts it
A multimodal atlas of the developing human heart reveals 21 tissue niches, shows fetal pacemaker cells recruiting their own nerve ...
Scientists discover the molecular switch that lets TNF trigger cell death
A new study identifies the E3 ubiquitin ligase HERC4 as the long-sought molecular switch that licenses RIPK1 to initiate TNF-induced ...
Tiny vesicles in cancer patients’ blood rewire T cells and blunt immunity
Plasma-derived small extracellular vesicles from head and neck cancer patients suppress T-cell proliferation, trigger apoptosis, and rewire immune checkpoint expression ...
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