Tag: Apoptosis

A machine-learning pipeline identified AML-selective small molecules and implicated glutathione reductase as a vulnerability that can be exploited in laboratory ...

A preclinical study reports that cannabidiol selectively impaired viability, migration, invasion, and clonogenic survival of cisplatin-resistant HPV-negative head and neck ...

Green-synthesized silver nanoparticles made from ginger extract showed selective toxicity to liver and breast cancer cells in vitro and reduced ...

Encapsulating the flavonoid kaempferol inside niosomal nanovesicles significantly increased its cytotoxic effect on SKOV3 ovarian cancer cells in vitro, a ...

In cultured primary mouse cortical neurons, the natural compound α-Cyperone restored survival after 96 hours of nutrient deprivation and strongly ...

A review of 86 cellular, animal and clinical studies reports multiple antitumor mechanisms for ginsenosides in liver-cancer models, while noting ...

A review finds that fungal compounds can suppress tumour growth, alter immunity and limit metastasis in skin-cancer models, but manufacturing, ...

A rat study reports that the flavonoid glycoside isorhoifolin countered cadmium-induced liver injury by suppressing the TLR4/MyD88/TRAF6/NF-κB inflammatory cascade, restoring ...

A cell-model study identifies clusterin as a downregulated gene in sepsis-associated acute lung injury and shows that CLU overexpression limits ...

In a cell-culture study, boldine increased hyperthermia-induced apoptosis in AGS gastric cancer cells in association with a weakened HSF1–HSP stress ...

A ROCK inhibitor partially preserved seminiferous tubule structure and reduced apoptosis in busulfan-treated mice, though sperm parameters remained below control ...

Researchers at the University of Cologne have identified a shared metabolic vulnerability in small cell lung cancer, where all cell ...

An integrated analysis of human carotid plaque transcriptomes and macrophage experiments suggests that elevated BCAP31 in atherosclerotic lesions may reflect ...

A new preclinical and retrospective clinical study reports that tumor-intrinsic CXCR5 coordinates CD8-positive T cell recruitment and p38-dependent apoptotic signaling, ...

A multi-stage virtual screening campaign against the c-Myc/Max dimerization interface has identified two small molecules that suppress c-Myc protein, block ...

Human kidney transcriptomics associated ASPHD1 with adaptive proximal-tubule states, while cell experiments found that silencing it increased apoptosis- and ferroptosis-associated ...

A preclinical mouse study found that Gudan Wan reduced liver injury, inflammation and fibrosis while altering autophagy- and apoptosis-related proteins, ...

A cell-culture study found that AD-MSC-conditioned medium reduced HeLa-cell viability and was associated with increased apoptosis and altered SIRT2 and ...

In vitro PIK3CA silencing restored anoikis sensitivity and reduced aggressive behaviors in engineered anoikis-resistant rabbit aortic endothelial cells.

A standardized Caesalpinia spinosa extract reduced viability in mouse colorectal cancer cells alongside increased reactive oxygen species and caspase activation, ...