Klebsiella pneumoniae outer membrane vesicles boost biofilm growth and carry biofilm-related mRNAs
A new study finds that outer membrane vesicles from Klebsiella pneumoniae promote biofilm formation and carry mRNAs tied to biofilm ...
Tag: antibiotic resistance
Scientists Build a Cephalosporin Triggered Prodrug That Delivers an Antibiotic Nucleoside in Resistant Bacteria
Researchers have synthesized cephalosporin-based pronucleotides of AZT that are cleaved by bacterial β-lactamases, achieving a first modest proof of concept ...
Amino Acid L-Histidine Restores Carbapenem Power Against NDM-Resistant Superbugs
New research shows that L-histidine resensitizes NDM-producing multidrug-resistant bacteria to carbapenems by directly inhibiting the enzyme and disrupting nickel homeostasis, ...
Engineered gut bacteria produce phages that prevent Salmonella infection in mice
An engineered gut bacterium delivered a Salmonella-targeting phage that multiplied on arrival and protected mice from oral infection in a ...
Orthopedic-service cultures show 2018–2025 resistance proxies, not infection incidence
A single-center study of 7,385 orthopedic-service culture-positive records found diverse pathogens and downward unadjusted trends in MRSA and carbapenem-resistant Klebsiella ...
Sequence Analysis Maps a Vast β-Lactamase Resistome Across Environments
A large-scale sequence survey identified roughly 108,000 putative β-lactamases across bacterial phyla and ecosystems, more than twelve-fold the number in ...
Bloodstream Infections at a West Bank Hospital Show High Antibiotic Resistance
A four-month retrospective review of 1,495 blood cultures at Jenin Governmental Hospital found 152 positive cultures, with 59.9 percent of ...
Flame-made nanosilver woven into chitosan fibers fights resistant wound bacteria
Researchers have combined flame spray pyrolysis and electrospinning to create chitosan-containing nanofiber dressings that release sustained silver ions from embedded ...
Niosome-Encapsulated Cefoxitin Shows Stronger Antibacterial and Antibiofilm Activity in Vitro
Encapsulating the antibiotic cefoxitin in niosomal nanovesicles halved inhibitory concentrations against Gram-positive bacteria and enabled activity against Gram-negative strains and ...
Tuned Iron-Manganese MOFs Boost Tetracycline Removal from Water
A bimetallic iron-manganese metal-organic framework with a 1:5 precursor ratio achieved the highest reported tetracycline hydrochloride adsorption capacity in the ...
PBP4 Emerges as a Target for Resistant Staphylococcal Infections
A 2026 review finds that Staphylococcus aureus PBP4 may offer a dual target for reversing noncanonical antibiotic resistance and limiting ...
Treatment-matched minority variants signal delayed culture conversion in rifampicin-resistant tuberculosis
A retrospective study of 229 patients with rifampicin-resistant or multidrug-resistant tuberculosis found that treatment-matched minority resistance variants at allele frequencies ...
Repurposed darifenacin and betamethasone potentiate streptomycin against resistant Staphylococcus aureus in vitro
An in vitro study found that a repurposed darifenacin-betamethasone formulation reduced the fitted streptomycin IC50 by 2.2-fold in a resistant ...
Single-center blood-culture analysis maps antibiotic resistance and dosing challenges in sepsis
A retrospective single-center analysis of 760 blood cultures from patients with sepsis found positive growth in 25.8% of samples and ...
Retrospective study finds diverse cephalosporin-resistant Enterobacterales in ICU pneumonia
A retrospective study of 80 adult ICU patients found diverse third-generation cephalosporin-resistant Enterobacterales and no statistically significant outcome differences between ...
Review outlines collateral-sensitivity strategies for antimicrobial resistance
A 2026 review summarizes proposed ways to use bacterial collateral sensitivity against multidrug-resistant infections while noting unresolved barriers to clinical ...
Cumulative SecA mutations strengthen azide selection in an E. coli prototype
A five-mutation SecA variant improved E. coli growth at sodium azide concentrations up to 200 micrograms per milliliter, but the ...
Eravacycline Shows Strong Real-World Results Against a Tricky Hospital Superbug in China
A multicentre Chinese observational study reports 90.3 percent clinical effectiveness for eravacycline-containing regimens against Stenotrophomonas maltophilia infections, with high microbiological ...
COVID-19 Reshaped Antibiotic Resistance in Children’s Urinary Infections, Six-Year Study Finds
A six-year Chinese surveillance study of nearly 5,700 pediatric urine isolates shows the COVID-19 pandemic significantly altered both the bacterial ...
How a Salmonella Infection Hid Inside a Toddler’s Brain Until Genetic Sequencing Caught It
A rare case of Salmonella group D meningitis and sepsis in a one-year-old girl required three hospitalizations, multiple antibiotics, and ...
