Tag: Alzheimer&#8217;s disease

A hybrid model pairing a ConvNeXt backbone with a Kolmogorov–Arnold Network head reaches 94.5 percent accuracy in four-way Alzheimer's staging ...

Cellular Bubbles and Molecular Trash Tags: A New Route for Antibody Drugs Into the Brain

University of Ottawa researchers report that extracellular vesicles can ferry engineered antibodies across the blood-brain barrier, and that tagging disease ...

Functional Ultrasound Brain-Computer Interfaces Move From Reading the Brain Toward Bidirectional Control

Brain-computer interfaces promise to restore movement and communication to people whose nervous systems no longer can, but the technology has ...

Left Brain, Right Brain: Why Rodent Disease Models Overlook Hemispheric Asymmetry

The practical implications of this systematic review extend well beyond academic taxonomy. When researchers pool data from both hemispheres without ...

Sex and Gender Reshape Disease Diagnosis: New Evidence Exposes Global Health Gaps

A new Frontiers research collection shows that ignoring sex and gender in diagnostic pathways actively drives global health inequalities across ...

Synapses Under Siege: How Plant Compounds May Rebuild the Brain’s Failing Connections in Alzheimer’s Disease

A new review reveals that synaptic failure—not plaque burden—is the strongest driver of Alzheimer's cognitive decline, and plant-derived phytochemicals may ...

Landmark Study Linking a MicroRNA to Stem Cell Survival in Alzheimer’s Models Is Rettracted Over Image Integrity Concerns

Frontiers in Neuroscience has retracted a 2018 study on microRNA Let-7f-5p and stem cell survival in Alzheimer's disease models after ...

Silent Synapses Wake Up: How Dormant Brain Connections Could Reshape Treatment of Disease

A sweeping review reveals how dormant silent synapses are activated through coordinated molecular machinery, and how their failure or overactivation ...

Shared Molecular Fingerprint of Alzheimer’s and Lewy Body Dementia Revealed in Human Brain Maps

A whole-transcriptome study of five brain regions from verified Alzheimer's and Lewy body dementia donors reveals a shared molecular signature ...

Mild Silicon Catalyst Turns Classic Reaction Into Assembly Line for New Alzheimer’s Drug Candidates

Chemists have used a mild silicon catalyst to rapidly build dihydropyrimidinethione compounds that inhibit the cholinesterase enzymes implicated in Alzheimer's ...

Real-World Data Show Lecanemab Is Mostly Safe but Flag a Stroke Signal

A combined real-world cohort and FAERS analysis finds lecanemab generally safe in Alzheimer's patients but flags a strong, unlabeled signal ...

Prior Flu Infection Reshapes Brain Inflammation and Behavior in Alzheimer’s Mice

A new mouse study shows that a prior H1N1pdm influenza infection reshapes social, affective, and memory behavior and intensifies neuroinflammation ...

A Hidden Brain Enzyme Emerges as the Secret Weapon Against Memory Decline in Aging

Scientists have discovered that an aging-induced secreted phospholipase called PLA2G2F acts as a neuron-derived signal that protects synapses, calms inflammatory ...

Blue molecule blueprint brightens fluorescent probes for disease imaging

University of Bath chemists have mapped how tiny structural changes tune the colour and brightness of azulene-based fluorescent probes, producing ...

Gut microbes may hold the key to Alzheimer’s and Parkinson’s disease

For decades, scientists have treated Alzheimer's and Parkinson's disease as problems of the brain alone. A new review published in ...

One Brain Map, Two Diseases: Alzheimer’s and Multiple Sclerosis Share a Genetic Signature of Shrinkage

A large trans-disease meta-analysis of more than 6,900 brain scans finds that Alzheimer's disease and multiple sclerosis share a common ...

Alzheimer’s Precision Medicine Must Fuse Cure and Care, Researchers Argue

A new Perspective argues that Alzheimer's precision medicine should treat cure and care as linked outputs of one continuously learning ...

Indanone Compounds Show Promise Against Parkinson’s and Alzheimer’s in Animal Studies

Indian researchers have synthesized arylidene indanone derivatives that restore motor function in Parkinson's model mice and memory in Alzheimer's model ...

How a Ubiquitin-Editing Enzyme in Microglia May Drive Alzheimer’s Inflammation

A new study identifies CYLD as a deubiquitinase that stabilizes microglial IKKβ, driving NF-κB–NLRP3 signaling, neuronal pyroptosis, and cognitive decline ...

Hidden DNA Repeats in the Brain May Shape Splicing and Disease Risk