Tag: Alzheimer’s disease

A case report describes how a protein numbering discrepancy caused the well-known APOE ε4-defining variant rs429358 to be misclassified as ...

A new study identifies the RNA-binding protein HuR as a repressor of tau exon 10 splicing and a regulator of ...

A PLOS Biology Perspective argues that immune and vascular cells, especially microglia, must be core components of neural organoids used ...

Rima Kaddurah-Daouk of UTHealth Houston has received a five-year, $12 million National Institute on Aging grant to study how mitochondrial ...

A single-nucleus multiome atlas of over 100,000 brain cells reveals disease-linked regulatory programs and potentially causal genetic variants in the ...

Researchers have developed SpatialZoomer, a spectral graph-based tool that automatically identifies the biologically meaningful scales in spatial transcriptomics data, revealing ...

A new mouse study shows that early chronic cerebral hypoperfusion spatially biases tau pathology and drives neuroinflammation at the onset ...

A two-year study of 506 older adults in the COSMOS cohort found that plasma biomarkers of neurodegeneration, including NT1, NfL, ...

A new review in Biogerontology argues that the Hippo–YAP/TAZ signalling pathway acts as a central hub linking brain ageing, neurodegeneration, ...

A new review charts how stem cell-derived human microglia, brain organoids and chimeric mice are overcoming the genetic and environmental ...

New research shows that the Alzheimer's risk gene BIN1 acts as a brake on microglial inflammation, and its loss exaggerates ...

Chronic inhibition of the enzyme soluble epoxide hydrolase with TPPU restored memory, cerebral blood flow, blood-brain barrier integrity, and neuronal ...

Mayo Clinic researchers report that ubiquitin phosphorylated at serine 65 is covalently attached to a soluble, oligomeric tau population in ...

Northwestern University researchers have identified a single water-defined hotspot on tau proteins that drives the misfolding cascade behind Alzheimer's and ...

A new Perspective in PLOS Biology proposes that Alzheimer's disease may impair activity-dependent adaptive myelination by gray-matter oligodendrocytes, contributing to ...

A new review proposes the Iron-Brain Nexus framework to explain why the brain is uniquely vulnerable to iron-dependent ferroptotic cell ...

Scientists have shown that the olfactory receptor Olfr544, found near amyloid plaques in Alzheimer's model mice, drives neurite outgrowth in ...

Researchers in New Delhi have developed a disposable paper-based electrochemical sensor that simultaneously detects Alzheimer's and Parkinson's disease biomarkers with ...

A co-led Buck Institute and Georgetown University team has won an ARPA-H award of up to $51.7 million to predict ...

A large postmortem study identified 107 brain DNA methylation sites linked to Alzheimer's pathology and showed that methylation partially mediates ...