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Home NEWS Science News Biology

Survival of the zebrafish: Mate, or flee?

Bioengineer by Bioengineer
July 18, 2019
in Biology
Reading Time: 3 mins read
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Study reveals zebrafish make an unexpected decision when faced with conflicting opportunities

When making decisions that are important to the species’ survival, zebrafish choose mating over fleeing from a threat. This decision, different compared to that of some other species, appears to be controlled by specific brain regions that respond to pheromone cues.

These findings by scientists at Harvard University and Novartis Institutes of BioMedical Research (NIBR) illuminate an aspect of basic biology that will be important as researchers use zebrafish to model neurological diseases that affect social behavior, such as autism and schizophrenia. The study is published in Current Biology.

“Animals and people make behavioral decisions, ones controlled by environmental challenges and modulated by their internal drives, but little is known about the biology of these choices,” said Mark Fishman, M.D., Harvard professor of stem cell and regenerative biology and senior author of the study. “We looked at a critical decision for the survival of the species in zebrafish, giving them the choice between mating and fleeing a threat.”

Wired for survival

To simulate a threat, the researchers used “skin extract,” a complicated mixture of pheromones that is released when a zebrafish is injured. When exposed to the substance, zebrafish usually show a strong alarm reponse, swimming quickly near the bottom of the tank and then freezing.

But when the zebrafish were mating, they ignored the threat. Moreover, they did not need to be mating to ignore the threat — being exposed to “mating water” that was previously conditioned by mating zebrafish was enough. This indicated to the researchers that the behavior was due to reproductive pheromones released in the water.

Digging deeper, the researchers used live imaging to identify specific brain regions that were activated by the mating and threat stimuli.

“When we presented both stimuli at the same time and looked at the brain, by and large we saw a response to just the reproductive stimulus, not the fear-inducing stimulus. And even further, the areas that were previously activated by the fear-inducing stimulus were now being suppressed,” said Gerald Sun, Ph.D., former NIBR postdoctoral scholar and co-lead author of the study.

An unexpected response

The zebrafish’s choice to continue mating in the face of a threat is the opposite of many other animals, including humans.

“The fish completely disregarded what is normally a very noxious, fearful stimulus, and that was really unexpected,” Sun said. “One potential explanation for why zebrafish have adopted this strategy is that they lay eggs that are externally fertilized. Humans and live-bearing fish make the opposite decision to flee a threat, because they need to survive for the next generation to be propagated.”

A model to study behavioral decisions

With a better understanding of zebrafish biology, researchers can use the animal model to study social and other behaviors.

“It’s important to establish what are the normal behaviors of zebrafish. Then you can study zebrafish as a model for diseases that affect social behavior, like autism and schizophrenia,” said Carmen Diaz-Verdugo, NIBR postdoctoral scholar and co-lead author of the study. “Once you define a well-established behavior and know the brain area responsible for it, then you can create genetic models that behave differently and use them for drug discovery.”

Although human brains are more complex than those of zebrafish, they still have a primitive component.

“We all have certain innate responses to the world around us. One hopes that with humans, you can modulate these to a certain degree. But on the other hand, your limbic system — your ‘fish brain’ — will play a big part in how you respond in different situations,” Fishman said. “We anticipate that elements of the underlying circuitry will be conserved and used for similar purposes in other species, although playing out in a species-specific manner.”

###

Media Contact
Jessica Lau
[email protected]
http://dx.doi.org/10.1016/j.cub.2019.06.047

Tags: BiologyMedicine/HealthneurobiologyOlfactory/Taste
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