• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Friday, July 1, 2022
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Study shows how low-protein intake during pregnancy can cause renal problems in offspring

Bioengineer by Bioengineer
May 5, 2021
in Biology
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

In an article published in PLOS ONE, scientists at a FAPESP-supported research center describe the impact of hypoproteinemia on the expression of microRNAs associated with kidney development in rat embryos.

IMAGE

Credit: Patrícia Aline Boer


Besides being underweight, babies born to women whose diet lacked sufficient protein during pregnancy tend to have kidney problems resulting from alterations that occurred while their organs were forming during the embryonic stage of their development.

In a study published in PLOS ONE, researchers affiliated with the University of Campinas (UNICAMP) in the state of São Paulo, Brazil, discovered the cause of the problem at the molecular level and its link to epigenetic phenomena (changes in gene expression due to environmental factors such as stress, exposure to toxins or malnutrition, among others).

According to the authors, between 10% and 13% of the world population suffer from chronic kidney disease, a gradual irreversible loss of renal function that is associated with high blood pressure and cardiovascular disorder.

The study, conducted at the Obesity and Comorbidities Research Center (OCRC), resulted from PhD research by first author Letícia de Barros Sene with a fellowship from FAPESP.

OCRC is a Research, Innovation and Dissemination Center (RIDC) funded by FAPESP.

In the article, the researchers describe the molecular pathways involved in the proliferation and differentiation of embryonic and fetal kidney cells. They obtained this knowledge by sequencing microRNAs (often called miRNAs) from the offspring of rats fed a low-protein diet while gestating. MirRNAs are small non-coding RNAs that regulate gene expression.

“We know low-protein intake during pregnancy tends to lead to a 28% decrease in the number of the offspring’s nephrons, the structures that filter blood in the kidneys. The resulting overloading of nephrons has several consequences. In the case of rats, pups become hypertensive only ten weeks after birth, when they are still considered young,” Patrícia Aline Boer, a member of the OCRC team and last author of the article, told Agência FAPESP. A healthy kidney has about a million nephrons.

Fetal programming

There has been a great deal of research in recent decades on the links between maternal health during pregnancy and child development, especially focusing on a field known as developmental origins of health and disease (DOHaD).

“In humans, these links were first observed after World War Two as a result of what’s known as the ‘Dutch famine’ [Hongerwinter], when the Nazis blocked food supplies to the Netherlands. Scientific studies showed that babies born to women who starved while pregnant in this period were underweight and developed high blood pressure, alterations in response to stress, heart problems, propensity to diabetes, and increased insulin resistance,” said Boer, who is president of DOHaD Brazil.

Since then, this epigenetic phenomenon has been studied in greater depth using animal experiment models. To understand at the molecular level what triggered the reduction in the number of nephrons, the OCRC researchers analyzed expression of miRNAs and target genes in fetal kidneys (metanephros) of rats at 17 days of gestation.

“We know the drop in the number of nephrons isn’t a genetic but an epigenetic effect,” Boer said. “It’s caused by something in the environment. In this case, gene expression is altered by the stress of hypoproteinemia. The DNA sequence doesn’t change. The expression of some genes in the offspring is altered, and the alteration can be heritable – it can be transmitted to future generations. We studied mirRNAs because they’re very important to genetic expression and alterations not associated with changes in DNA.”

Compared analysis between rats fed a regular protein diet (17% of daily calorie intake) and a second group fed a low-protein diet (6%) during pregnancy revealed alterations in 44 miRNAs – seven of which in genes associated with the proliferation and differentiation of cells essential to nephron development, researchers found. Genetic sequencing, immunohistochemistry and morphological analysis demonstrated that maternal protein restriction changed the expression of miRNAs and proteins involved in renal development as early as the 17th day of gestation.

“Previous research showed a 28% reduction in nephrogenesis, and in our study, there was a 28% decrease in the cells that give rise to nephrons. The proportion was the same, which means there must be some kind of signaling during the embryonic period that the organ has to adapt to a low-protein intake,” Boer said.

Other examples of fetal adaptation to malnutrition leading to alterations in organ development can be found in nature, Boer explained. “In our study, we observed that stem cells [which will become nephrons] differentiate very rapidly and that there was more differentiation and less proliferation of the cells that form nephrons,” she said.

The article “Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus” (doi: 10.1371/journal.pone.0246289) by Letícia de Barros Sene, Wellerson Rodrigo Scarano, Adriana Zapparoli, José Antônio Rocha Gontijo and Patrícia Aline Boer is at: journals.plos.org/plosone/article?id=10.1371/journal.pone.0246289.

Media Contact
heloisa reinert
[email protected]

Original Source

https://agencia.fapesp.br/35771/

Related Journal Article

http://dx.doi.org/10.1371/journal.pone.0246289

Tags: CardiologyDiet/Body WeightEnvironmental HealthMedicine/HealthMetabolism/Metabolic DiseasesMolecular BiologyNutrition/NutrientsPediatricsUrogenital System
Share12Tweet8Share2ShareShareShare2

Related Posts

Whale Breaching

Whales learn songs from each other in a cultural ‘deep dive’

July 1, 2022
Red crossbill

Birds warned of food shortages by neighbor birds change physiology and behavior to prepare

July 1, 2022

Aging-US | Time makes histone H3 modifications drift in mouse liver

June 30, 2022

CDC Designates New England Center of Excellence in Vector-borne Diseases at UMass Amherst

June 30, 2022
Please login to join discussion

POPULAR NEWS

  • Pacific whiting

    Oregon State University research finds evidence to suggest Pacific whiting skin has anti-aging properties that prevent wrinkles

    37 shares
    Share 15 Tweet 9
  • University of Miami Rosenstiel School selected for National ‘Reefense’ Initiative focusing on Florida and the Caribbean

    35 shares
    Share 14 Tweet 9
  • Sharks may be closer to the city than you think, new study finds

    34 shares
    Share 14 Tweet 9
  • Saving the Mekong delta from drowning

    37 shares
    Share 15 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

VaccinesVirusViolence/CriminalsVehiclesWeather/StormsUniversity of WashingtonUrbanizationVirologyWeaponryVaccineZoology/Veterinary ScienceUrogenital System

Recent Posts

  • Putting the brakes on a bacterium that is a major cause of GI distress
  • Hearing better with skin than ears
  • The formation process of unstable unknown radical states visualized clearly for the first time!
  • Development of ultra-thin, high-efficiency piezoelectric elements that generate electricity from movements in daily life
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Posting....