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Home NEWS Science News Cancer

Study Reveals Blood Cancer Patients on Bruton Tyrosine Kinase Inhibitors Can Safely Continue Treatment During COVID-19 Vaccination

Bioengineer by Bioengineer
April 1, 2025
in Cancer
Reading Time: 4 mins read
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In a groundbreaking development for patients suffering from blood cancer, recent research led by the University of Birmingham and the Oxford Clinical Trials Research Unit has provided important insights regarding the management of chronic lymphocytic leukaemia (CLL) during COVID-19 vaccination. The findings, published in the esteemed journal Lancet Haematology, indicate that patients receiving Bruton Tyrosine Kinase inhibitors (BTKi) should maintain their ongoing treatment even while being vaccinated against COVID-19. This revelation challenges previous assumptions based on observational data and underscores the need for evidence-based guidance for this vulnerable population.

Chronic lymphocytic leukaemia, the most common adult leukaemia, presents unique hurdles, particularly in the context of vaccination against infections like COVID-19. Patients with CLL are noted to have a diminished antibody response to vaccines compared to the general populace, an issue exacerbated when these patients are on BTKi medications like ibrutinib or acalabrutinib. Given the heightened risk of severe infection associated with both CLL and COVID-19, understanding the optimal approach to vaccination while on BTKi therapy became a crucial area of focus for researchers.

The IMPROVE trial aimed specifically to test the hypothesis that a temporary cessation of BTKi therapy during a three-week window surrounding COVID-19 vaccination could enhance the antibody response in patients. Prior studies had suggested that pausing such therapies might lead to improved immune responses, galvanizing the research team to explore this avenue rigorously. Thus, the trial involved a randomized control methodology, a gold standard in clinical research, allowing for a robust assessment of the impacts of treatment interruption versus continued therapy.

Recruiting from 11 hospitals across the United Kingdom, the trial involved 99 adults who had been on BTKi therapy for over a year and had a well-controlled status of chronic lymphocytic leukaemia. Participants were randomized into two distinct groups: one group would halt their medication for three weeks—one week prior to and two weeks following the vaccination—while the other group would continue their treatment without interruption. This design permitted scientists to meticulously measure immune responses at three critical time points: prior to vaccination, three weeks after, and twelve weeks subsequent to vaccination.

Results from the study indicated a noteworthy lack of significant difference in antibody levels between the groups that paused therapy and those that continued without interruption. Those continuing their BTKi medication maintained a comparable quality of immune response regarding antibody production and cellular immunity. Additionally, this consistency in outcomes was observed at the twelve-week mark post-vaccination, further emphasizing the reliability of the data and the conclusions drawn from it.

These findings stand in stark contrast to the previously endorsed approach from observational studies, which had suggested that a pause might yield better immune responses. The results from the IMPROVE trial thus provide essential clarity for healthcare professionals and patients alike, reinforcing that the continuation of BTKi therapy does not demand alteration in light of COVID-19 vaccinations. In fact, the study provides a sense of reassurance to blood cancer patients that their prescribed medication need not be disrupted unnecessarily, which could have implications for their overall health management.

Highlighting the variability in immune responses among patients undergoing BTKi treatment, the researchers express the critical need for further investigation in this field. Future studies backed by UK Research and Innovation (UKRI) and Blood Cancer UK are now in the planning stages, set to delve deeper into the intricacies of how CLL patients respond to COVID-19 vaccinations and explore potential avenues for enhancing these responses. Blood samples collected during the trial will play a pivotal role in this further investigation, shedding light on the immunological behaviors present in these patients.

Dr. Helen Parry, Associate Professor at the University of Birmingham’s Department of Immunology and Immunotherapy and Chief Investigator of the IMPROVE trial, articulates the study’s implications succinctly. She emphasizes that the research offers valuable insights, particularly for individuals impacted by blood cancer and for their healthcare providers, affirming that pausing BTKi treatment around the time of COVID-19 vaccination is not supported by the evidence and should not be advocated.

In summary, the IMPROVE trial has made significant strides in addressing a critical question regarding the management of chronic lymphocytic leukaemia in the context of COVID-19 vaccination. The study not only digs deep into the biological underpinnings of immunological response but also showcases the importance of conducting rigorous, controlled trials to guide clinical practice effectively. The revelations from this research consequently lay the groundwork for future inquiries into the optimization of vaccine responses among blood cancer patients, ensuring that their care remains evidence-based and responsive to their unique healthcare needs.

As the pandemic continues to evolve, the findings from ongoing research like the IMPROVE trial will be essential for shaping health care strategies for vulnerable populations. With an ongoing commitment to patient-centric approaches, the scientific community is poised to make further advances in cancer treatment while prioritizing the health and safety of those most at risk.

Subject of Research: People with chronic lymphocytic leukaemia (CLL) receiving Bruton Tyrosine Kinase inhibitors (BTKi) during COVID-19 vaccination.
Article Title: A 3-week pause versus continued Bruton tyrosine kinase inhibitor use during COVID-19 vaccination in individuals with chronic lymphocytic leukaemia (IMPROVE trial): a randomized, open-label, superiority trial.
News Publication Date: 31-Mar-2025.
Web References: The Lancet Haematology
References: DOI
Image Credits: None.

Keywords: COVID-19 vaccines, antibody therapy, cancer patients, blood cancer, clinical trials, tyrosine kinase inhibitors.

Tags: antibody response in CLL patientsblood cancer treatment during vaccinationBruton Tyrosine Kinase inhibitorschronic lymphocytic leukaemia managementCOVID-19 and blood cancer riskCOVID-19 vaccination for cancer patientsevidence-based guidance for CLLIMPROVE trial resultsongoing treatment during COVID-19safety of BTKi therapyvaccination challenges in chronic lymphocytic leukaemiavaccination strategies for blood cancer

Tags: blood cancer patientsBruton Tyrosine Kinase Inhibitorschronic lymphocytic leukaemiaclinical trialCOVID-19 vaccination
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