• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Saturday, August 2, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Science

SibFU researchers develop a biosensor enhanced with gold nanoparticles for express diagnostics of stress and toxicological pollution

Bioengineer by Bioengineer
March 15, 2019
in Science
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

A group of researchers is in the process of developing a highly sensitive biosensor designed to detect toxic substances using bioluminescent inhibitory analysis as well as to monitor a biomarker for indicating stress and cancer, namely heat shock proteins 90 (Hsp90). The work is carried out at the School of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, under the supervision of Dr. Rajeev Ranjan (India), postdoctoral researcher and senior researcher at the laboratory of bioluminescent biotechnology, and Dr. Valentina Kratasyuk, chair of biophysics (School of Fundamental Biology and Biotechnology SibFU) and leading researcher at the laboratory of bioluminescent biotechnology.

“”We study universal mechanisms of interaction between nanomaterials and biological objects of different levels of organization necessary for the development of biosensors in which the enhancement of the bioluminescent signal, and hence the sensitivity of the analysis, is achieved by integrating nanoparticles with bioluminescent probes, namely adenosine triphosphate (ATP) and flavin mononucleotide (FMN). ATP and FMN are the key substrates of luciferase of fireflies and luminous bacteria. We have chosen these biological objects not accidentally since both bioluminescent systems are widely used in the development of bioluminescent biosensors, which allow obtaining a prompt and reliable analysis of the level of various substances. We have chosen gold nanoparticles (AuNP) to enhance bioluminescence and observed that signal amplification occurred during binding, for example, for ATP with AuNP up to 150 %,””– said Dr. Rajeev Ranjan.

The enhanced luminescence properties of AuNP can be used to monitor the Hsp90 protein, an elevated level of which is traditionally considered to be a biomarker for indicating stress and cancer.

“”We developed a biological module to monitor the stress-induced protein on the basis of gold nanoparticles associated with adenosine triphosphate molecules. This type of protein has increased stability. When carrying out a luminescent reaction using the obtained biological module in the presence of Hsp90, a refolding (restoration of the structure) of luciferase occurs under certain temperature conditions, and the kinetics of the luminescent reaction changes, which allows measuring the amount of Hsp90, and thus detecting stress or diagnosing oncology diseases. We have confirmed that the developed biological module of the biosensor can be used, among other things, for the detection of heavy metals, as well as the control of stress overload in athletes. The researches in this direction are in progress. In the future, we plan to use the resulting nanoparticles for increasing the sensitivity of bioluminescent analysis methods,”” — clarifies Dr. Kratasyuk.

The project is supported by a grant from the Russian Foundation for Basic Research.

###

Media Contact
Yaroslava Zhigalova
[email protected]
http://www.sfu-kras.ru/en/news/21328

Tags: BiochemistryBiotechnologyMedicine/Health
Share12Tweet7Share2ShareShareShare1

Related Posts

Five or more hours of smartphone usage per day may increase obesity

July 25, 2019
IMAGE

NASA’s terra satellite finds tropical storm 07W’s strength on the side

July 25, 2019

NASA finds one burst of energy in weakening Depression Dalila

July 25, 2019

Researcher’s innovative flood mapping helps water and emergency management officials

July 25, 2019
Please login to join discussion

POPULAR NEWS

  • Blind to the Burn

    Overlooked Dangers: Debunking Common Myths About Skin Cancer Risk in the U.S.

    60 shares
    Share 24 Tweet 15
  • Dr. Miriam Merad Honored with French Knighthood for Groundbreaking Contributions to Science and Medicine

    46 shares
    Share 18 Tweet 12
  • Study Reveals Beta-HPV Directly Causes Skin Cancer in Immunocompromised Individuals

    38 shares
    Share 15 Tweet 10
  • Sustainability Accelerator Chooses 41 Promising Projects Poised for Rapid Scale-Up

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Macrophage-T Cell Interaction Boosts SLAMF1 in TB Defense

Strawberry Notch 1 Protects Neurons by Regulating Yeats4

Revolutionary AI Tool Requires Minimal Data to Analyze Medical Images

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.