• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Tuesday, August 26, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Scientists engineer unique ‘glowing’ protein

Bioengineer by Bioengineer
May 30, 2019
in Biology
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Vera Nazarenko et al.

Biophysicists from the Moscow Institute of Physics and Technology have joined forces with colleagues from France and Germany to create a new fluorescent protein. Besides glowing when irradiated with ultraviolet and blue light, it is exceedingly small and stable under high temperatures. The authors of the paper, published in the journal Photochemical & Photobiological Sciences, believe the protein holds prospects for fluorescence microscopy. This technique is used in research on cancer, infectious diseases, and organ development, among other things.

Fluorescence microscopy is a method for studying living tissue that relies on induced luminescence. After being exposed to laser radiation at a particular wavelength, some proteins emit light at a different wavelength. This induced “glow” can be analyzed using a special microscope. Researchers append such fluorescent proteins to other proteins via genetic engineering to make the latter ones visible to the microscope and observe their behavior in cells. Fluorescence microscopy proved so scientifically valuable that one Nobel Prize was awarded for its discovery, followed by another one for radically improving the method’s accuracy.

Up until now, the fluorescent proteins used for such observations had several flaws. They were vulnerable to heat, fairly bulky, and only glowed in the presence of oxygen.

“For one thing, our protein is more thermostable than its analogues: It only denaturates at 68 degrees Celsius,” said the paper’s lead author Vera Nazarenko from the MIPT Laboratory of Structural Analysis and Engineering of Membrane Systems. “It is also miniature, while most of the currently used fluorescent proteins are rather bulky. On top of that, it can emit light in the absence of oxygen.”

The team originally identified the protein with these remarkable properties in the cells of a the thermophilic bacterium — that is, one which lives in high-temperature environments, such as hot springs. The researchers then genetically engineered a DNA sequence that reproduced the protein’s fluorescent segment but not the other parts, which would make the molecule larger.

By introducing the gene that encodes the protein into the cells of another bacterium, Escherichia coli, the team turned it into a factory mass-producing the fluorescent protein with unique properties.

Researchers studying the processes that occur in living cells have been waiting for a protein combining these crucial features for a long time. By introducing it into cells, they can now obtain essential data on cell life and death. To name a few applications, fluorescence microscopy is seen as one of the best tools for investigating the mechanism behind malignant tumor genesis and development. It is also useful for research on cell signaling and organ development.

The proteins previously used in fluorescence microscopy were bulky and thermally unstable, putting limitations on the method. Thanks to the MIPT team, that obstacle has been eliminated.

###

Media Contact
Varvara Bogomolova
[email protected]

Original Source

https://mipt.ru/english/news/scientists_engineer_unique_glowing_protein

Related Journal Article

http://dx.doi.org/10.1039/c9pp00067d

Tags: BacteriologyBioinformaticsBiologyBiomedical/Environmental/Chemical EngineeringBiotechnologyCell Biology
Share13Tweet8Share2ShareShareShare2

Related Posts

Key Genes Drive Organic Acid Accumulation in Cherry

Key Genes Drive Organic Acid Accumulation in Cherry

August 25, 2025
blank

Introducing a Breakthrough Tool to Monitor Infant Development Beginning at Just 16 Days Old

August 25, 2025

Genetic Diversity in Nile Tilapia: A Conservation Review

August 25, 2025

Flamingos Unlock the Secret to Longevity, New Study Finds

August 25, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    146 shares
    Share 58 Tweet 37
  • Molecules in Focus: Capturing the Timeless Dance of Particles

    142 shares
    Share 57 Tweet 36
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    115 shares
    Share 46 Tweet 29
  • Neuropsychiatric Risks Linked to COVID-19 Revealed

    81 shares
    Share 32 Tweet 20

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

JUNO Successfully Completes Liquid Filling and Commences Data Acquisition

Targeted Prostate Screening: Reducing Harm through Age Stratification

Aortic Valve Guides Umbilical Artery Catheter Placement

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.