• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Saturday, August 9, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

Scientists developed key principles for creating an artificial vessel

Bioengineer by Bioengineer
October 8, 2020
in Chemistry
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Researchers implanted a polymer scaffold as a vascular prosthesis into the rat abdominal aorta and monitored the process of its bioresobtion for 16 months.

IMAGE

Credit: Peter the Great St.Petersburg Polytechnic University

Researchers from St. Petersburg provided a unique experiment. They implanted a polymer scaffold as a vascular prosthesis into the rat abdominal aorta and monitored the process of its bioresobtion for 16 months. An artificial vessel was formed where the scaffold was located. It posess similar characteristics as a natural vessel. The scaffold itself showed high patency, biocompatibility and non-toxicity. The results were published in the Cell and Tissue Biology journal. This study brings scientists closer to the creation of an artificial tissue-engineered vascular graft.

The study was conducted by multidisciplinary team from Peter the Great St.Petersburg Polytechnic University (SPbPU), Pavlov First Saint Petersburg State Medical University and Institute of Macromolecular Compounds.

Coronary and peripheral artery bypass grafting is commonly used to relieve the symptoms of angina and other vascular deficiencies. Synthetic vascular prostheses perform reasonably satisfactorily in high-flow, low-resistance conditions such as the large peripheral arteries, but they are not as suitable for small calibre arterial reconstructions (e.g., coronary or lower leg circulation). They are prone to thrombus induction, embolism and occlusion.

Therefore it is desirable to develop a low-cost artificial blood vessel with no biocompatibility problems in order to overcome these problems.

“Synthetic prosthesis does not undergo remodeling in the child’s body, that’s why reoperations will be required. These is one of the reasons for creation of artificial vessels”, – said Vladimir Yudin, head of the Department “Polymeric materials for tissue engineering and transplantation” SPbPU.

The researchers developed the synthetic tubular scaffold from a biodegradable polymer – polylactic acid, which is normally found in the human body. It is also approved by the FDA (Food & Drug Association) for medical use. The scaffold gradually dissolves in the body, and a vessel appears in its place.

“The scaffold consists of nano- and microfibers, which are very similar to the fibrous structure of the natural vessel. Host cells successfully proliferate on such graft. We studied its mechanical strength, porosity, hydrophobicity. The scaffold is safe”, – added Pavel Popryadukhin, researcher of that department.

Surgical experiments were carried out at the Pavlov University. The scaffold was sewn into the rat aorta using microsurgical techniques. After 16 months the scaffold was completely dissolved. The artificial vessel looked very similar to the natural one. However, aneurysm formation in the reconstruction zone was noted.

“We also obtained positive results: scaffold safety was proved during the long-term experiments. The possibility of new tissues formation on the scaffold was also shown. The scaffold has been proven to be non-toxic with high patency rates – 93%. This is very high value, which suggests that while a new vessel is being formed, the scaffold will be patent, ” – mentioned Guriy Popov, cardiovascular surgeon of the Pavlov University.

The next step is to seed and cultivate cells, which is responsible for strength, on the scaffold prior operation. This will help to solve the problem of aneurysms at the implantation site.

###

Media Contact
Raisa Bestugina
[email protected]

Related Journal Article

http://dx.doi.org/10.1134/S1990519X20040082

Tags: CardiologyClinical TrialsMedicine/HealthMolecular PhysicsNanotechnology/MicromachinesPolymer ChemistrySurgeryTransplantation
Share12Tweet8Share2ShareShareShare2

Related Posts

Bacterial Enzyme Powers ATP-Driven Protein C-Terminus Modification

Bacterial Enzyme Powers ATP-Driven Protein C-Terminus Modification

August 9, 2025
Machine-Learned Model Maps Protein Landscapes Efficiently

Machine-Learned Model Maps Protein Landscapes Efficiently

August 9, 2025

High-Definition Simulations Reveal New Class of Protein Misfolding

August 8, 2025

Organic Molecule with Dual Functions Promises Breakthroughs in Display Technology and Medical Imaging

August 8, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Molecules in Focus: Capturing the Timeless Dance of Particles

    137 shares
    Share 55 Tweet 34
  • Neuropsychiatric Risks Linked to COVID-19 Revealed

    77 shares
    Share 31 Tweet 19
  • Overlooked Dangers: Debunking Common Myths About Skin Cancer Risk in the U.S.

    61 shares
    Share 24 Tweet 15
  • Modified DASH Diet Reduces Blood Sugar Levels in Adults with Type 2 Diabetes, Clinical Trial Finds

    55 shares
    Share 22 Tweet 14

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Cachexia Index Predicts Gastric Cancer Impact

Non-Coding Lung Cancer Genes Found in 13,722 Chinese

Unraveling Mitophagy in Bronchopulmonary Dysplasia

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.