• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Tuesday, October 7, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Saudi Arabians: Somatic mutations in breast cancer: New opportunities

Bioengineer by Bioengineer
September 6, 2025
in Health
Reading Time: 4 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

‘Worldwide, breast cancer is the most common cancer in women.’

Oncotarget published “Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients” which reported that the association between genetic polymorphisms in tumor suppressor genes and the risk of BCa has been studied in many ethnic populations with conflicting conclusions while Arab females and Saudi Arabian studies are still lacking.

The authors screened a cohort of Saudi BCa patients by NGS using a bespoke gene panel to clarify the genetic landscape of this population, correlating and assessing genetic findings with clinical outcomes.

They identified a total of 263 mutations spanning 51 genes, including several frequently mutated.

Among the genes analyzed, the highest mutation rates were found in PIK3CA, BRCA2, BRCA1, TP53, MSH2, PMS2, BARD1, MLH1, CDH1, RAD50, MSH6, NF1, in addition to others.

They identified multiple common recurrent variants and previously reported mutations.

They also reveal the landscape of the mutations associated with BCa in Saudi women, highlighting the importance of routine genetic sequencing in implementation of precision therapies in KSA.

Dr. Malak Abedalthagafi from The King Fahad Medical City and King Abdulaziz City for Science and Technology said, “Worldwide, breast cancer is the most common cancer in women.”

“Worldwide, breast cancer is the most common cancer in women.”

A positive ER and/or PR, either positive HER2 or negative HER2, and high levels of Ki67 suggest a luminal B BCa subtype, which makes up less than 20% of all BCa cases and has lower survival rates than luminal A.

The absence of ER and PR expression accompanied by high expression of HER2 and proliferation gene clusters and low expression of luminal and basal clusters, as detected by IHC, suggests a HER2-enriched BCa subtype, which accounts for 10% to 15% of all cases and has a poorer prognosis than luminal cancers.

Three significant pathways govern mammary gland and BCa stem cell development:

Estrogen receptor signaling;

HER2 signaling; and

Canonical Wnt signaling.

In ER signaling, estrogen binds membrane estrogen receptors and triggers a cascade of events that ultimately promote the binding of nuclear estrogen receptors with estrogen response elements.

Other pathways involved in BCa development include cyclin-dependent kinase signaling, notch signaling, sonic hedgehog signaling, breast tumor kinase signaling, and PI3K/AKT/mTOR signaling.

WES also facilitated both the identification of the FANCM gene as a susceptible gene for triple-negative BCa and the association of XCR1, DLL1, TH, ACCS, SPPL3, CCNF and SRL with BCa.

In this study, they screened a cohort of Saudi BCa patients using a cancer-specific gene panel to ascertain the mutation spectrum and explore the possible clinical implications of the identified somatic variants in BCa development.

The Abedalthagafi Research Team concluded in their Oncotarget Research Output that the authors identified somatic mutation variants in Saudi BCa patients; BRCA1, BRCA2, TP53, and PIK3CA were found to be among the most common.

In total, they identified 39 novel mutations that were not reported before and were predicted to be pathogenic.

Their study has pertinent limitations.

Further, their limited sample size, particularly for limited somatic genomics aberrations analyzes, may limit generalizability.

More regional studies are still needed.

###

DOI – https://doi.org/10.18632/oncotarget.27909

Full text – https://www.oncotarget.com/article/27909/text/

Correspondence to – Malak Abedalthagafi – [email protected]

Keywords – breast cancer, PIK3CA, BCa, Saudi Arabia, BRCA

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud – https://soundcloud.com/oncotarget

Facebook – https://www.facebook.com/Oncotarget/

Twitter – https://twitter.com/oncotarget

LinkedIn – https://www.linkedin.com/company/oncotarget

Pinterest – https://www.pinterest.com/oncotarget/

Reddit – https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact

[email protected]

18009220957×105

Copyright © 2021 Impact Journals, LLC

Impact Journals is a registered trademark of Impact Journals, LLC

Media Contact
Ryan James Jessup
[email protected]

Original Source

https://www.oncotarget.com/news/pr/somatic-mutations-in-breast-cancer-new-opportunities/

Related Journal Article

http://dx.doi.org/10.18632/oncotarget.27909

Tags: BRCA genesBreast CancercancerMedicine/HealthSaudi Arabiasomatic mutationsTargeted Therapies
Share12Tweet8Share2ShareShareShare2

Related Posts

Comparing Mental Health Services: Refugees vs. General Population

October 7, 2025

Lobeline Boosts Stress Granules, Cell Death in Glioblastoma

October 7, 2025

Career Adaptability Patterns in Chinese Cardiovascular Nurses

October 7, 2025

Once-Weekly Insulin Icodec: Efficacy and Safety in India

October 7, 2025
Please login to join discussion

POPULAR NEWS

  • New Study Reveals the Science Behind Exercise and Weight Loss

    New Study Reveals the Science Behind Exercise and Weight Loss

    95 shares
    Share 38 Tweet 24
  • New Study Indicates Children’s Risk of Long COVID Could Double Following a Second Infection – The Lancet Infectious Diseases

    94 shares
    Share 38 Tweet 24
  • Ohio State Study Reveals Protein Quality Control Breakdown as Key Factor in Cancer Immunotherapy Failure

    74 shares
    Share 30 Tweet 19
  • New Insights Suggest ALS May Be an Autoimmune Disease

    72 shares
    Share 29 Tweet 18

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Comparing Mental Health Services: Refugees vs. General Population

Scientists Find Enlarged Spinal Cord Regions in Fish, Previously Seen Only in Tetrapods

Study Reveals Solar Energy as the Most Affordable Power Source Globally

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 63 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.