• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Saturday, January 16, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Renal dopamine signaling prevents kidney injury and improves blood pressure in mice

Bioengineer by Bioengineer
June 2, 2016
in Health
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

mice 5

Dopamine signaling in the kidneys plays a critical role in blood pressure regulation and is responsible for nearly half of the salt and water excretion that occurs in response to increased dietary salt intake. Notably, genetic deletion of any of the 5 dopamine receptors expressed in the kidney causes hypertension in mice.

Additionally, genetic polymorphisms in specific dopamine receptor subtypes are associated with susceptibility to kidney injury in humans. In this issue of JCI Insight, Prasad Konkalmatt and colleagues at George Washington University and the University of Maryland Medical School demonstrate that expression of the D2 dopamine receptor (DRD2) protects mice against kidney injury and hypertension. Konkalmatt and colleagues found that kidney-specific deletion of DRD2 increased expression of inflammatory and profibrotic factors and elevated blood pressure in mice. Moreover, these effects were exacerbated in a mouse model of kidney ischemia/reperfusion injury. Restoration of DRD2 expression decreased the expression of inflammatory and profibrotic factors, normalized blood pressure, and protected mice from kidney injury. These findings suggest that DRD2-directed therapies may be useful for the treatment of renal injury.

###

TITLE:

Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure

AUTHOR CONTACT:

Prasad Konkalmatt
The George Washington University
Email: [email protected]

View this article at: http://insight.jci.org/articles/view/85888?key=d8cbf7468ef392f51d48

JCI Insight is the newest publication from the American Society of Clinical Investigation, a nonprofit honor organization of physician-scientists. JCI Insight is dedicated to publishing a range of translational biomedical research with an emphasis on rigorous experimental methods and data reporting. All articles published in JCI Insight are freely available at the time of publication. For more information about JCI Insight and all of the latest articles go to http://www.insight.jci.org.

Media Contact

Corinne Williams
[email protected]
@jclinicalinvest

http://www.jci.org

The post Renal dopamine signaling prevents kidney injury and improves blood pressure in mice appeared first on Scienmag.

Share12Tweet7Share2ShareShareShare1

Related Posts

IMAGE

Rapid blood test identifies COVID-19 patients at high risk of severe disease

January 15, 2021
IMAGE

Special interests can be assets for youth with autism

January 15, 2021

Principles of care established for young adults with substance use disorders

January 15, 2021

USC study measures brain volume differences in people with HIV

January 15, 2021
Next Post
blank

3-D printing of patterned membranes opens door to rapid advances in membrane technology

blank

Dietary supplement may prevent and reverse severe damage to aging brain, research suggests

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    The map of nuclear deformation takes the form of a mountain landscape

    53 shares
    Share 21 Tweet 13
  • Blood pressure drug may be key to increasing lifespan, new study shows

    44 shares
    Share 18 Tweet 11
  • New drug form may help treat osteoporosis, calcium-related disorders

    38 shares
    Share 15 Tweet 10
  • New findings help explain how COVID-19 overpowers the immune system

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Ecology/EnvironmentInfectious/Emerging DiseasesPublic HealthMedicine/HealthCell BiologycancerClimate ChangeGeneticsMaterialsChemistry/Physics/Materials SciencesTechnology/Engineering/Computer ScienceBiology

Recent Posts

  • Rapid blood test identifies COVID-19 patients at high risk of severe disease
  • Conductive nature in crystal structures revealed at magnification of 10 million times
  • Howard University professor to receive first Joseph A. Johnson Award
  • Nanodiamonds feel the heat
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In