How the Human Blood Proteome Changes Over Time With Ageing and Disease
For decades, medicine has relied on a deceptively simple assumption: that many measurements in the blood remain relatively stable within each person. A cholesterol value,...
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Epigenetic changes in stromal cells drive disease-promoting tissue niches in Crohn’s disease
Crohn’s disease is often described as an immune disorder, but a new study suggests that the cells forming the body’s connective-tissue framework may be just...
mRNA delivery system activates T cells for in-body CAR T generation
Scientists have developed an mRNA delivery system that can generate functional chimeric antigen receptor (CAR) T cells inside the body without requiring antibody targeting or...
Biomimetic artificial cells reveal how mechanics regulate immune synapses
Researchers have introduced a synthetic “cell” platform designed to do something conventional biomaterials and biochemical assays have struggled to achieve: reproduce the mechanical, chemical and...
Multi-element doping boosts iron-rich sodium layered oxides for ampere-hour sodium-ion batteries
Sodium-ion batteries have long been viewed as a promising alternative to lithium-ion technology, particularly for applications where low cost, abundant raw materials and large-scale energy...
Simple, Efficient End-to-End Methods Prepare Quantum Thermal and Ground States
Quantum computers may eventually transform the study of molecules, magnetic materials and strongly interacting particles, but one obstacle stands between today’s hardware and many of...
Optical Microcantilever Creates Piconewton-Sensitive Stethoscope for Cells
For decades, scientists have searched for ways to measure the tiny forces generated by living cells without disturbing the very behaviors they want to observe....
Integrated thermal sensing maps vascular morphology for haemodynamic monitoring
Wearable health monitors have become increasingly sophisticated at measuring heart rate, blood oxygenation and other physiological signals, yet one important source of uncertainty has remained...
Mammalian Eggs Store Ready-to-Activate Degradative and Cytoskeletal Complexes in Cytoplasmic Lattices
A new study reports that mammalian eggs do not simply contain a passive mixture of proteins waiting for fertilization. Instead, they appear to organize key...
New strategy enables asymmetric α-arylation and alkenylation of amines and ethers
A new strategy for building chiral carbon–carbon bonds could give synthetic chemists a more practical alternative to one of the field’s most familiar tools: stoichiometric...
Illicit fentanyl use more than doubles medical use in United States
A nationwide analysis of nearly 300,000 patients suggests that illicit fentanyl exposure has become substantially more common than medically supervised use, offering one of the...
Firefighting linked to biological changes in blood and urine within 24 hours
Firefighters experience measurable changes in proteins circulating through their bodies within a day of battling a fire, according to a new study from UTHealth Houston....
Large Mammals Transform Atlantic Forest Soil Chemistry, Boosting Fertility
In Brazil’s Atlantic Forest, large mammals are doing far more than moving through the trees. Tapirs, peccaries, deer, and agoutis are acting as living agents...
Giant Sunflower Family Genome Assembly Opens Path to New Perennial Crops
A pair of prairie plants with roots deep enough to reach several meters into the soil has moved closer to becoming a new generation of...
Dan Landau named inaugural chair of Weill Cornell’s computational biomedicine department
Weill Cornell Medicine is launching a new Department of Systems and Computational Biomedicine, an initiative designed to bring genomics, artificial intelligence and patient-centered research into...