Measuring Neonatal Encephalopathy Severity Beyond Traditional Definitions
Neonatal encephalopathy has long been treated as a condition that can be sorted into neat clinical categories: mild, moderate or severe. A new perspective in...
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Biomedical Engineering Education Challenges Highlighted at ASEE 2025 Conference
Biomedical engineering is entering a period of extraordinary scientific opportunity—and equally extraordinary educational pressure. At the 2025 Annual Conference of the American Society for Engineering...
Nationwide Survey Examines Psychological and Economic Burdens of Home LVAD Management
A nationwide survey has brought renewed attention to the hidden costs of living with a left ventricular assist device, or LVAD, revealing how long-term home...
Correction: Improving Actuation-Inhalation Coordination in Ventilated Patients Using Automated MDI Delivery
A correction to the article “Towards an Improved Understanding of the Actuation-Inhalation Coordination in Ventilated Patients Using an Automated Metered Dosage Inhaler (MDI) Delivery System”...
Modeling Amorphous Nimodipine Dispersions Reveals Links Between Properties and Drug Exposure
Nimodipine is a drug with a frustrating contradiction at its core. It can be highly effective in relaxing blood vessels and improving cerebral blood flow,...
3D Maps of Intact Ovaries Reveal How Ovarian Reserves Age
A new three-dimensional view of intact ovaries is offering scientists a more complete picture of how the ovarian reserve changes with age, challenging the idea...
TIM3-targeted venetoclax delivery overcomes resistance and restores NK cell activity in AML
Acute myeloid leukemia (AML) is a fast-moving blood cancer in which immature myeloid cells accumulate in the bone marrow and crowd out the normal cells...
CD98hc Controls Brain Angiogenesis and Blood–Brain Barrier Integrity via Localized Integrin–FAK Signaling
A previously underappreciated protein in the cells lining blood vessels may hold the key to how the brain builds and maintains its protective vascular system....
Catalysts Enable Asymmetric Carbonyl–Ene Reactions Between Unactivated Aldehydes and Alkenes
A reaction long regarded as one of synthetic chemistry’s most stubborn challenges has moved closer to practical use. In a study published in Nature Catalysis,...
Brain mega-enhancers compartmentalize transcriptionally active long genes
A previously unrecognized layer of genome organization has been identified in the mammalian brain, where exceptionally long genes and the enormous enhancers that regulate them...
hnRNPK condensates boost enhancer–promoter looping and RNA polymerase II recruitment
Scientists have identified a molecular organizer that helps connect distant regulatory regions of the genome with the genes they control, solving a longstanding question about...
Red List Models Underestimate Climate Extinction Risks for Range-Shifting Species
A Hidden Climate Threat Is Putting Range-Shifting Species at Greater Risk of Extinction Species are moving as the climate changes, but the tools used to...
How the Human Blood Proteome Changes Over Time With Ageing and Disease
For decades, medicine has relied on a deceptively simple assumption: that many measurements in the blood remain relatively stable within each person. A cholesterol value,...
Epigenetic changes in stromal cells drive disease-promoting tissue niches in Crohn’s disease
Crohn’s disease is often described as an immune disorder, but a new study suggests that the cells forming the body’s connective-tissue framework may be just...
mRNA delivery system activates T cells for in-body CAR T generation
Scientists have developed an mRNA delivery system that can generate functional chimeric antigen receptor (CAR) T cells inside the body without requiring antibody targeting or...