Consensus Roadmap Guides Clinical Trials for Rare Childhood CNS Tumors
Rare childhood central nervous system tumours have exposed one of the most stubborn weaknesses in modern oncology: science can move faster than the clinical-trial systems...
NEWS INDEX
Proteomics Links Environmental and Genetic Parkinson’s Models to Purine Metabolism
Parkinson’s disease has long been described as a disorder of dopamine-producing neurons, but a new comparative study suggests that its molecular story may be far...
Wearable Devices Track Activity Rhythms to Reveal Biological Aging Over Time
A smartwatch may be doing far more than counting steps. It may be quietly recording a shifting portrait of how the body ages—minute by minute,...
Succinate Worsens Obesity-Linked Osteoarthritis Through SUCNR1 Activation, Succinylation, and Mitochondrial Dysfunction
A metabolic by-product best known for its role in cellular energy production may be helping obesity turn osteoarthritis into a more aggressive and destructive disease,...
Genetic Basis of Cytokine Autoantibodies Linked to Common Disease Risk
Cytokines are among the immune system’s most powerful molecular messengers. These small proteins coordinate inflammation, guide the development of immune cells and help the body...
How Mitochondria Change During Orthoflavivirus Infections in Humans and Mosquitoes
A new study in npj Viruses is examining how orthoflaviviruses manipulate one of the most dynamic systems inside infected cells: the mitochondria. The article, “Mitochondrial...
How Phages Target Hidden Intracellular Bacteria Behind Persistent Urinary Tract Infections
Urinary tract infections are commonly treated as infections that unfold in an exposed, fluid-filled environment. Yet some of the bacteria responsible for recurrent disease can...
Genomic Study Reveals Betacoronavirus Evolution in Wild Mice and Small Mammals
Wild rodents are emerging as important subjects in the effort to understand how coronaviruses evolve outside human populations. A new study in npj Viruses examines...
Zanidatamab Shows Promise in Early-Stage HER2-Positive Breast Cancer Trial
A new clinical study is drawing attention to the possibility of treating HER2-positive breast cancer before surgery with a next-generation antibody designed to attack the...
Early-Onset Inflammatory Bowel Disease Advances, Yet Health Inequities Persist
A global shift is transforming the medical story of inflammatory bowel disease in children. In a commentary on Yue and colleagues’ population-based study, researchers describe...
Alanine tRNA Fragments and MEG3 Variant Vary with Tissues and Parkinson’s Severity
Parkinson’s disease may be leaving behind a molecular trail far more intricate than previously understood. A new study published in npj Parkinson’s Disease reports that...
GLP-1 Drugs and Tuberculosis Risk in People With Type 2 Diabetes
A new study published in Nature Communications is putting a widely used class of diabetes medicines under the microscope, asking whether glucagon-like peptide-1 receptor agonists...
In-Situ Friction Stir Forging Produces Near-Net-Shape Soft Magnetic Composite Parts
Soft magnetic components are the quiet workhorses of modern technology. They channel and reshape magnetic fields inside electric motors, transformers, inductors, sensors and power-conversion systems,...
Scientists uncover design rules for high-performance thermoelectric materials
A new theoretical study from Tokyo Metropolitan University could change how scientists search for the next generation of thermoelectric materials—substances capable of converting wasted heat...
New analysis maps China’s ozone pollution pathways and mitigation strategies
China’s progress in reducing fine particulate pollution has exposed a more elusive threat in the nation’s atmosphere: ozone. A new article in Engineering warns that...