Preclinical Data Require Clinical Context for Accurate Interpretation
The path from a promising laboratory result to an effective clinical treatment is often described as a pipeline, but a new Nature article argues that...
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Extinction intervention erases fear memories through locus coeruleus dopamine and D2 receptors
A new study reports that a behavioral intervention can do more than suppress the outward expression of fear: it may erase the neural trace of...
Scientists Compare Human Brains and Organoids Side by Side
For nearly 15 years, scientists have been building organoids—three-dimensional structures grown from stem cells that mimic selected features of organs in miniature. Researchers at the...
RTN4IP1 Drives Triple-Negative Breast Cancer Progression and Metastasis Through Metabolic Reprogramming
Triple-negative breast cancer (TNBC), one of the most aggressive forms of breast cancer, may be driven by a previously underappreciated mitochondrial protein that helps tumor...
Recyclable Energy Storage Device Designed for Sustainability
Smartphones, smartwatches and small drones may soon have access to a different kind of rechargeable power source—one designed not only to store energy, but also...
Stroller-running parents report less than half the injury rate of other runners
For parents who lace up their running shoes while pushing a stroller, the extra weight and altered stride may seem like a recipe for injury....
Scientists create innovative technique to 3D-print blood vessel networks
More than 100,000 people in the United States are currently waiting for an organ transplant, while another potential recipient joins the list roughly every 10...
Research finds some wars face a persistent risk of escalation
Military leaders often enter conflicts believing they can control their size, duration and intensity. A new statistical analysis led by researchers at the University of...
Case Western Leads NIH Partnership Developing Rapid Chairside Oral Cancer Test
Cleveland researchers are developing a rapid, noninvasive test that could help dentists determine within minutes whether a suspicious lesion in the mouth is likely to...
Eco-friendly processing lowers costs of novel material for water decontamination
Industrial wastewater could soon be treated with a material that is not only highly effective at capturing toxic lead, but also substantially cheaper and less...
AI-Powered Stethoscopes May Miss Heartbeats in Pets
A digital stethoscope promoted as an intelligent aid for detecting heart disease may be far less reliable in dogs and cats than in humans, according...
Over a decade of Seattle suburban observations reveals where sensitive birds avoid
A nearly 30-year bird survey in Washington’s Puget Sound lowlands has delivered a message that could reshape how residential development is planned: New housing does...
How Obesity Triggers Cellular Stress Through Unfolded Protein Response and NRF2 Signaling
Obesity is often described as a disorder of excess fat accumulation, but a new review argues that this familiar definition misses the biological turmoil unfolding...
Newborn Blood Spots Reveal Population-Wide Genetic Risk for Childhood Cancer
A routine newborn blood test could become an early-warning system for childhood cancer, according to a new population-based genomic study published in Nature Communications. Researchers...
How China’s Major Urban Agglomerations Link Urban Resilience and Carbon Efficiency
China’s biggest urban clusters are becoming the frontline of a global environmental experiment: how can densely populated regions remain resilient to shocks while producing economic...