• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Tuesday, September 9, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Oral bacteria ‘battle royale’ helps explain how a pathogen causes hospital infections

Bioengineer by Bioengineer
April 8, 2019
in Health
Reading Time: 3 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Jessica Mark Welch and Gary Borisy, PNAS.1522149113

Hundreds of different bacterial species are living inside your mouth. Some are highly abundant, while others are scarce. A few of these oral bacteria are known pathogens. Others are benign, or even beneficial.

Scientists know the genetic makeup of about 70 percent of oral bacteria. What they don’t know is which species would live the longest without nutrients in a “battle royale”–so they decided to find out. The results help explain how certain dangerous bacteria are able to persist in a sterile hospital environment and infect patients.

In a paper publishing later this week in the Proceedings of the National Academy of Sciences journal, researchers from the Forsyth Institute, the J. Craig Venter Institute, the University of Washington, and the University of California, Los Angeles, describe their discovery that three closely related species of bacteria belonging to the family Enterobacteriaceae outlived all other oral bacteria in long-term starvation or “doomsday” experiment.

“A number of species from that family are known to cause infections in hospitals,” said Dr. Xuesong He, an Associate Member of Staff at the Forsyth Institute and co-author of the study.

To create a battle of bacteria, researchers placed hundreds of samples of oral bacteria from human saliva into test tubes. The bacteria, which are accustomed to living in the nutrient-rich mouth, were starved in their new environment. Each day, scientists checked the samples to see which bacteria were still alive.

Nearly every bacterial species died within the first couple of days. But three species–Klebsiella pneumoniae, Klebsiella oxytoca, and Providencia alcalifaciens–survived the longest, with Klebsiella pneumoniae and Klebsiella oxytoca surviving for more than 100 days.

Researchers were surprised to find that Klebsiella were among the champions of this bacterial combat. In their natural environment of the oral cavity, Klebsiella are considered an underdog. They account for only about .1 percent of all microbes in the mouth. But in an extreme environment deprived of all nutrients, Klebsiella reigned supreme while the bugs normally found in high abundance rapidly died off.

How did Klebsiella pull off such a feat? To answer this question, scientists analyzed the genome of the bacteria on the first day of “battle” and then again on day 100.

“When we look at the genome content, it turns out that these Enterobacteriaceae species have larger genomes than other oral bacteria, giving them the capacity to tap into more diverse energy sources,” said Dr. He. The researchers found that the Klebsiella had undergone genetic mutations that may have allowed them to survive and continue to function, even without a food source.

Scientists describe Klebsiella species as opportunistic pathogens. In healthy people, they live in the mouth peacefully, crowded by other microbes and unable to grow or cause trouble. But outside the mouth, where few other bacteria survive, Klebsiella is king. They persist on hospital surfaces, like sinks or tables. If a patient with a compromised immune system makes contact with Klebsiella, that patient could develop an infection.

“Oral fluids like saliva are a rich source of bacteria and viruses. We want to understand how pathogens, that are typically rare, can become dominant and then also persist for long periods outside the body to be later transmitted,” explains co-author Dr. Jeff McLean, a Professor at the University of Washington.

Infections by Klebsiella can result in a number of dangerous conditions including pneumonia and meningitis. One of the reasons Klebsiella infections are so dangerous is that Klebsiella are particularly adept at developing resistance to antibiotics, as well as transferring this drug resistance to neighboring bacteria.

“The finding that these Klebsiella species survive longer than their more benign neighbors in mixtures of saliva is likely to have a great deal of clinical significance, as multiple virulent outbreaks of antibiotic-resistant Klebsiella have been traced back to hospital sinks and drains,” said Dr. Jonathon L. Baker, Ph.D. Baker is the Ruth L. Kirschstein NRSA Fellow in the Department of Genomic Medicine at the J. Craig Venter Institute and lead author of the study.

This research also helps illuminate a key ecological dynamic of bacterial communities.

“From a big picture point of view, this is a huge step forward towards understanding microbial social structure and ecology,” said Dr. Wenyuan Shi, CEO and Chief Scientific Officer at the Forsyth Institute. “This study begins to address a fundamental question in biology–how, evolutionarily, was a microbial community built, and what takes place as the community dies?”

###

Media Contact
Alexandra Nicodemo
[email protected]

Original Source

https://www.forsyth.org/news/battle-royale-oral-bacteria-hospital-infections

Tags: BiologyDentistry/Periodontal DiseaseInfectious/Emerging DiseasesMedicine/HealthMicrobiology
Share12Tweet8Share2ShareShareShare2

Related Posts

ChatGPT in Nursing: Benefits and Challenges Explored

September 9, 2025

UT San Antonio Health Science Center Ranks in Top 2% Worldwide for Research Output

September 9, 2025

University of Minnesota Medical School Secures $3.3 Million NIH Grant for Groundbreaking 5-Year Study on Infants Born with CMV

September 9, 2025

Clinical Trial Indicates Pre-Surgery Immunotherapy as Promising Treatment for Rare Cancer

September 9, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    151 shares
    Share 60 Tweet 38
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    116 shares
    Share 46 Tweet 29
  • First Confirmed Human Mpox Clade Ib Case China

    56 shares
    Share 22 Tweet 14
  • Physicists Develop Visible Time Crystal for the First Time

    50 shares
    Share 20 Tweet 13

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Revamping Stage IV Lung Cancer Care Through Digital Networks

Eco-Friendly Nutrient Management with Biostimulants in Crops

Kennesaw State Researcher Innovates Electronic Nose Technology to Combat Foodborne Illness

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.