• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Thursday, October 23, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Immunology

New salmonella proteins discovered

Bioengineer by Bioengineer
December 16, 2020
in Immunology
Reading Time: 2 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Image: Sandy Westermann / SCIGRAPHIX

Salmonella are bacteria that can cause food poisoning with severe diarrhoea. If they penetrate from the intestine into the blood system, this can lead to sepsis, life-threatening inflammatory reactions in the entire organism. Since salmonellae are also becoming increasingly resistant to antibiotics, new approaches are being sought to combat them.

An international research team, led by scientists from Würzburg, shows how to succeed in this search in the new research journal microLife.

More than 100 new proteins found

In a bioinformatic reassessment of the Salmonella genome, the team led by JMU doctoral student Elisa Venturini identified many unknown small proteins that may play a crucial role in infection. As a result, the number of known small Salmonella proteins has grown by 139 to over 600.

The small protein MgrB, which consists of 47 amino acids, stood out in the analyses. If the gene containing the blueprint for this protein is switched off, the salmonellae can no longer infect human cells. Although the protein had been studied before, this important function had not been recognised. This has only now been achieved thanks to a new combinatorial approach. Among other things, three data sets that had been generated in earlier infection studies were used for this purpose.

Blueprint for other bacteria too?

“Hopefully our approach will provide a blueprint that can also be applied to other organisms for which data sets already exist,” says Venturini. The study has clearly shown that the method can still bring new relevant genes to light even in comprehensively studied organisms such as salmonella: The scientific community now has a priority list of previously unknown infection-related small salmonella proteins for further investigation.

###

The research groups involved

The Würzburg laboratories of the Professors Jörg Vogel, Cynthia Sharma, Alexander Westermann, and Lars Barquist were involved in the study. In addition, groups from the Albert Ludwigs University of Freiburg and the University of Greifswald were involved, as part of the DFG priority programme SPP2002 “Small Proteins in Prokaryotes, an Unexplored World”. Scientists from Australia, China and the Wellcome Trust Sanger Insitute in the UK also contributed to the study.

Media Contact
Prof. Dr Jörg Vogel
[email protected]

Original Source

https://www.uni-wuerzburg.de/en/news-and-events/news/detail/news/new-salmonella-proteins-discovered/

Related Journal Article

http://dx.doi.org/10.1093/femsml/uqaa002

Tags: BacteriologyBioinformaticsBiologyCell BiologyInfectious/Emerging DiseasesMicrobiology
Share12Tweet8Share2ShareShareShare2

Related Posts

IMAGE

UMass Amherst grad student awarded fellowship for food allergy research

July 23, 2021
IMAGE

Less-sensitive COVID-19 tests may still achieve optimal results if enough people tested

July 22, 2021

Public trust in CDC, FDA, and Fauci holds steady, survey shows

July 20, 2021

USC study shows male-female differences in immune cell function

July 19, 2021
Please login to join discussion

POPULAR NEWS

  • Sperm MicroRNAs: Crucial Mediators of Paternal Exercise Capacity Transmission

    1277 shares
    Share 510 Tweet 319
  • Stinkbug Leg Organ Hosts Symbiotic Fungi That Protect Eggs from Parasitic Wasps

    308 shares
    Share 123 Tweet 77
  • ESMO 2025: mRNA COVID Vaccines Enhance Efficacy of Cancer Immunotherapy

    163 shares
    Share 65 Tweet 41
  • New Study Suggests ALS and MS May Stem from Common Environmental Factor

    132 shares
    Share 53 Tweet 33

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Redefining Birth: Ethics of Artificial Womb Technology

Highlighting the Hidden Risks of Heart Disease

South American Long-Necked Dinosaur Adapted for Easy Bipedal Stance

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 66 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.