• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Saturday, April 10, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Cancer

New cancer immunotherapy drugs linked to arthritis in some patients

Bioengineer by Bioengineer
June 24, 2016
in Cancer
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

cancer cells

Case reports on 13 cancer patients suggest that a small number of cancer patients taking the immunotherapy drugs ipilimumab and nivolumab may be at some higher-than-normal risk of developing autoimmune joint and tissue diseases, including inflammatory arthritis, according to a preliminary study by Johns Hopkins Medicine researchers.

“I don’t think anyone is particularly surprised that rheumatologic disorders might be a complication of drugs that boost the immune system,” says study author Laura C. Cappelli, M.D., a rheumatologist at the Johns Hopkins University School of Medicine. But the new study, however small in sample size, she says, is believed to be the largest published case series of a link between the drugs and the diseases.

The patients described in the new case report make up only about 1.3 percent of the total patients treated with drugs — singly or in combination — at The Johns Hopkins Hospital from 2012 to 2016, Cappelli says, but if further research confirms a cause-and-effect relationship, the rate is likely an underestimation of how common rheumatologic diseases are in patients taking so-called immune checkpoint inhibitors. She notes that patients with only mild joint pain, for instance, or those with already deteriorating health from their cancers may not have been referred to the rheumatology clinic for their symptoms.

“We keep having referrals coming in from our oncologists as more patients are treated with these drugs,” says Clifton Bingham, M.D., associate professor of medicine at the Johns Hopkins University School of Medicine and director of the Johns Hopkins Arthritis Center. “In particular, as more patients are treated with combinations of multiple immunotherapies, we expect the rate to go up.”

Between 2012 and 2016, 13 patients at the Johns Hopkins Kimmel Cancer Center who were taking one or both drugs to treat their cancers developed new-onset arthritis or sicca syndrome, a set of autoimmune conditions causing dry eyes and mouth, including Sjogren’s syndrome. The cases were described online June 15 in Annals of Rheumatic Diseases.

“In 2015, our rheumatology clinic started getting more and more referrals from our oncology department to evaluate patients treated with immunotherapies,” says Cappelli. “And the patients we saw had very severe, highly inflammatory arthritis. They needed even higher doses of steroids to control their symptoms compared to what is needed in other forms of inflammatory arthritis, like rheumatoid arthritis.”

Ipilimumab and nivolumab — as well as a growing number of other checkpoint inhibitors now in clinical trials — are designed to turn off the molecular “checkpoints” that some cancers use to evade the body’s natural immune system cells. When the drugs work, they allow the immune system to detect — and attack — tumor cells. But because they also turn up the activity of the immune system as a whole, the drugs can trigger immune-related side effects, including so-called autoimmune responses, in which the body attacks its own cells and tissues.

Cappelli notes that clinical trials of ipilimumab and nivolumab found an increased risk of inflammatory bowel diseases, lung inflammation, autoimmune thyroid disease and pituitary gland inflammation. But those trials were designed primarily to determine efficacy against cancer and not to fully examine all features of rheumatologic side effects, she says.

Overall, Cappelli and her colleagues identified 13 patients who had developed previously undiagnosed or reported rheumatologic symptoms after their treatment with the immune checkpoint inhibitors. All were over 18 and had been treated for melanoma, nonsmall-cell lung cancer, small-cell lung cancer or renal carcinoma. Eight were taking a combination therapy with both ipilimumab and nivolumab, while five were only taking one of the two drugs. Nine of the patients developed inflammatory arthritis, and the other four were diagnosed with sicca syndrome. With treatment, all patients were able to get their rheumatologic diseases under control, though not eliminated.

Cappelli says she wants the case report to raise awareness among both patients and clinicians that rheumatologic side effects may occur with the drugs. “It is important when weighing the risk-benefit ratio of prescribing these drugs,” she says. “And it’s important for people to be on the lookout for symptoms so they can see a rheumatologist early in an effort to prevent or limit joint damage.”

Cappelli, Bingham and their rheumatology colleagues are planning further collaboration with Johns Hopkins oncologists to better track the incidence of rheumatologic disease in patients taking immunotherapy drugs and determine whether any particular characteristics put cancer patients at higher risk of rheumatologic complications.

###

Additional study authors include Ana Kristina Gutierrez, Alan Baer, Jemima Albayda, Rebecca Manno, Uzma Haque, Evan Lipson, Karen Bleich, Ami Shah, Jarushka Naidoo, Julie Brahmer and Dung Le of the Johns Hopkins University School of Medicine.

Funding for the studies described in the Annals of Rheumatic Diseases article was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the Jerome L. Greene Foundation.

Media Contact

Marin Hedin
[email protected]
410-502-9429
@HopkinsMedicine

http://www.hopkinsmedicine.org

The post New cancer immunotherapy drugs linked to arthritis in some patients appeared first on Scienmag.

Share46Tweet7Share2ShareShareShare1

Related Posts

IMAGE

Men with low health literacy less likely to choose active surveillance for prostate cancer after tumor profiling

April 10, 2021
IMAGE

Vaping vs. smoking: Impact on cells compared

April 9, 2021

Artificial Intelligence could ‘crack the language of cancer and Alzheimer’s’

April 8, 2021

Excellent outcomes reported for first targeted therapy for pediatric Hodgkin lymphoma

April 8, 2021

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    Terahertz accelerates beyond 5G towards 6G

    851 shares
    Share 340 Tweet 213
  • Jonathan Wall receives $1.79 million to develop new amyloidosis treatment

    59 shares
    Share 24 Tweet 15
  • UofL, Medtronic to develop epidural stimulation algorithms for spinal cord injury

    55 shares
    Share 22 Tweet 14
  • A sturdier spike protein explains the faster spread of coronavirus variants

    43 shares
    Share 17 Tweet 11

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

GeneticsCell BiologyBiologyPublic HealthMedicine/HealthcancerInfectious/Emerging DiseasesMaterialsTechnology/Engineering/Computer ScienceClimate ChangeChemistry/Physics/Materials SciencesEcology/Environment

Recent Posts

  • Men with low health literacy less likely to choose active surveillance for prostate cancer after tumor profiling
  • Level of chromosomal abnormality in lung cancer may predict immunotherapy response
  • Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis
  • Better metric for thermoelectric materials means better design strategies
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In