• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Wednesday, October 22, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Long-term blood pressure variation and risk of dementia

Bioengineer by Bioengineer
November 13, 2019
in Health
Reading Time: 3 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: rawpixel, Pixabay

In a new research study published in the open access journal PLOS Medicine, Albert Hofman and colleagues at Erasmus MC University Medical Center, Rotterdam, the Netherlands and Harvard T.H. Chan School of Public Health, Boston, United States report that people who experienced substantial changes in blood pressure over the long term were at greater risk of dementia than those who did not.

The authors studied 5,273 people in Rotterdam, the Netherlands at a mean age of 67.6 years, who were free of dementia at the beginning of the study and were followed-up for 14.6 years. After adjustment for age, sex and other factors that could affect the findings, at 15 years people in the highest quintile, who exhibited an increase in systolic blood pressure, had a hazard ratio of 3.31 (95% Confidence Interval 2.11-5.18) for risk of dementia as compared with those in the quintile with the least change in blood pressure. Those in the lowest quintile, with the largest fall in systolic blood pressure, had a hazard ratio of 2.20 (95% CI 1.33-3.63) for dementia risk, again compared to those with the least change. Variations in both systolic and diastolic blood pressure led to similar findings.

Assuming that Hofman and colleagues’ findings reflect a causal relationship between blood pressure variation and dementia, the authors note a “potential to prevent dementia through targeting blood pressure variability above and beyond the mere control of conventional blood pressure limits”, and note that the association observed over a long time period implies that interventions should be implemented earlier in life to yield potential benefits.

###

Research Article

Funding:

The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam; Netherlands Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture and Science; the Ministry for Health, Welfare and Sports; the European Commission (DG XII), and the Municipality of Rotterdam. This work was partially supported by an unrestricted grant from the Janssen Prevention Center. YM was sponsored by the Rose Travelling Fellowship. The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Competing Interests:

The authors have declared that no competing interests exist.

Citation:

Ma Y, Wolters FJ, Chibnik LB, Licher S, Ikram MA, Hofman A, et al. (2019) Variation in blood pressure and long-term risk of dementia: A population-based cohort study. PLoS Med 16(11): e1002933. https://doi.org/10.1371/journal.pmed.1002933

Image Credit: rawpixel, Pixabay

Author Affiliations:

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

In your coverage please use this URL to provide access to the freely available paper: http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002933

Media Contact
PLOS Medicine
[email protected]

Related Journal Article

http://dx.doi.org/10.1371/journal.pmed.1002933

Tags: AgingAlzheimerCardiologyGerontologyHealth Care Systems/ServicesMedicine/Health
Share12Tweet8Share2ShareShareShare2

Related Posts

Kidney Transplant Ethics in Older Adults Explored

October 22, 2025

Innovative Approaches to Monkeypox: Diagnostics, Vaccines, Treatments

October 22, 2025

Boosted Wound Healing with Crocin-Loaded Nanohydroxyapatite

October 22, 2025

Ultrasound Reveals Arterial Thickness and Homocysteine in Diabetics

October 22, 2025
Please login to join discussion

POPULAR NEWS

  • Sperm MicroRNAs: Crucial Mediators of Paternal Exercise Capacity Transmission

    1273 shares
    Share 508 Tweet 318
  • Stinkbug Leg Organ Hosts Symbiotic Fungi That Protect Eggs from Parasitic Wasps

    305 shares
    Share 122 Tweet 76
  • ESMO 2025: mRNA COVID Vaccines Enhance Efficacy of Cancer Immunotherapy

    143 shares
    Share 57 Tweet 36
  • New Study Suggests ALS and MS May Stem from Common Environmental Factor

    131 shares
    Share 52 Tweet 33

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Kidney Transplant Ethics in Older Adults Explored

Innovative Approaches to Monkeypox: Diagnostics, Vaccines, Treatments

Boosted Wound Healing with Crocin-Loaded Nanohydroxyapatite

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 66 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.