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Home NEWS Science News Chemistry

Having a ball: Crystallization in a sphere

Bioengineer by Bioengineer
September 21, 2020
in Chemistry
Reading Time: 3 mins read
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Credit: Institute of Industrial Science, the University of Tokyo

Tokyo, Japan–Crystallization is the assembly of atoms or molecules into highly ordered solid crystals, which occurs in natural, biological, and artificial systems. However, crystallization in confined spaces, such as the formation of the protein shell of a virus, is poorly understood. Researchers are trying to control the structure of the final crystal formed in a confined space to obtain crystals with desired properties, which requires thorough knowledge of the crystallization process.

A research group at Institute of Industrial Science, The University of Tokyo and Fudan University led by Hajime Tanaka and Peng Tan used a droplet of a colloid–a dispersion of liquid particles in another liquid, like milk–as a model for single atoms or molecules in a sphere. Unlike single atoms or molecules, which are too small to easily observe, the colloid particles were large enough to visualize using a microscope. This allowed the researchers to track the ordering of single particles in real time during crystallization.

“We visualized the organization process of colloid particles in numerous droplets under different conditions to provide a picture of the crystallization process in a sphere,” says Tan.

Based on their observations, the team proposed that the crystallization process involved three stages: initial ordering on the surface “skin” of the droplet, nucleation and growth in the core of the droplet, and then slow ripening of the whole structure. First, a skin consisting of a single layer of ordered colloid particles rapidly formed on the droplet surface. Next, crystallization occurred in the core of the droplet, far from the crystallized skin. The competition between crystallization in these two regions controlled the structure of the final crystal.

The researchers found that the “soft” (long-range) interactions between the negatively charged colloid particles affected their organization and the resulting crystal structure. These soft interactions are dominated by kinetics, that is, the interactions that form the fastest, rather than those that use the least energy to give the thermodynamically stable structure, illustrating that kinetics plays an important role in crystallization in a confined space. It was already known that thermodynamics contributes strongly to the final structure of crystals. The team’s findings confirmed that kinetics are also integral, furthering our knowledge of crystallization in confined spaces.

“This research deepens our understanding of the crystallization process in geometrically constrained systems, leading researchers one step closer to achieving controlled growth of crystals at a very small scale,” explains Tanaka.

Detailed knowledge of the crystal formation process in confined systems may enable crystals with designed structures, such as nanoparticles for specific electronics applications, to be obtained, giving researchers greater ability to control the structure and thus the properties of valuable materials.

###

The article “Morphology selection kinetics of crystallisation in a sphere” can be found at DOI: 10.1038/s41567-020-0991-9

About Institute of Industrial Science (IIS), the University of Tokyo

Institute of Industrial Science (IIS), the University of Tokyo is one of the largest university-attached research institutes in Japan.

More than 120 research laboratories, each headed by a faculty member, comprise IIS, with more than 1,000 members including approximately 300 staff and 700 students actively engaged in education and research. Our activities cover almost all the areas of engineering disciplines. Since its foundation in 1949, IIS has worked to bridge the huge gaps that exist between academic disciplines and real-world applications.

Media Contact
Hajime Tanaka
[email protected]

Original Source

https://www.iis.u-tokyo.ac.jp/en/news/3358/

Related Journal Article

http://dx.doi.org/10.1038/s41567-020-0991-9

Tags: Atomic/Molecular/Particle PhysicsBiochemistryChemistry/Physics/Materials SciencesIndustrial Engineering/ChemistryMaterialsNanotechnology/MicromachinesOpticsPharmaceutical Sciences
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