• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Thursday, August 7, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

From cancer medication to antibiotic

Bioengineer by Bioengineer
December 16, 2019
in Health
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Modified cancer drug effective against multi-resistant bacteria

IMAGE

Credit: Andreas Heddergott / TUM

Antibiotic-resistant bacteria are increasingly the source of deadly infections. A team of scientists from the Technical University of Munich (TUM) and the Helmholtz Center for Infection Research (HZI) in Braunschweig have now modified an approved cancer drug to develop an active agent against multidrug-resistant pathogens.

The methicillin-resistant Staphylococcus aureus (MRSA) is the source of severe and persistent infections. Some strains are even resistant to multiple antibiotics. There is consequently an urgent need for new drugs effective against MRSA infections.

“The industrial development of new antibiotics is stalling and not keeping pace with the spread of antibiotic resistance. We urgently need innovative approaches to meet the need for new infection therapies that do not lead directly to renewed resistance,” says Prof. Eva Medina, director of the HZI Infection Immunology Research Group.

New antibiotic development strategies

One promising strategy is to test the potential effect of approved drugs on bacteria. “Our focus was on a class of human proteins, called kinases, which have many inhibitors to begin with,” explains study leader Stephan Sieber, professor of organic chemistry at TUM.

In this vein, the researchers chemically modified the active ingredient sorafenib, a cancer drug that is effective against MRSA, to achieve a stronger antibiotic effect. This led to the development of PK150, a molecule ten times more effective against MRSA than the original substance.

Multiple attacks prevent the development of resistance

The potent new agent targets various unconventional structures within the bacteria. Two targets were investigated in greater detail: For one, PK150 inhibits an essential protein involved in bacterial energy metabolism. For another, it acts on the cell wall.

In contrast to previously known antibiotics such as penicillin and methicillin, which interfere with cell wall formation, PK150 acts indirectly. It knocks the protein production in bacteria off kilter. As a result, the bacteria release more proteins that control the cell wall thickness to the outside, causing the cells to burst.

In mice, PK150 has proven to be effective against MRSA in a variety of tissues. While staphylococci rapidly develop resistance to other antibiotics, the researchers did not observe the development of any resistance to PK150.

Effectiveness against biofilms and persisters

Eva Medina and Dr. Katharina Rox, a pharmacologist from the Department of Chemical Biology at HZI, showed that PK150 has favorable pharmacological properties. It can be administered as a tablet, for example, and remains stable in the body for several hours. “As a result of the chemical changes to the molecule, PK150 no longer binds to human kinases, but acts very specifically against bacterial targets,” says Sieber.

And PK 150 has another benefit: “MRSA infections are very often chronic, as the bacteria can become dormant. PK150 even kills these, as well as germs protected in biofilms,” says Prof. Dietmar Pieper, head of the HZI research group “Microbial Interactions and Processes”.

In the context of the aBACTER project, Prof. Sieber’s team is now further optimizing PK150 to enter the clinical development phase.

###

The work was funded by the European Community (via the European Research Council (ERC) and the CHEMMINE research program), the German Research Foundation (DFG) within the Cluster of Excellence Center for Integrated Protein Science Munich (CIPSM) and the SFB 1035 Collaborative Research Center, the Chemical Industry Fund, the Boehringer Ingelheim Fund, the German Center for Infection Research (DZIF), the National Science Foundation (NSF) and the National Institute of General Medical Sciences (the latter two, USA). The aBACTER project is funded by the German Federal Ministry of Education and Research (BMBF) as part of the VIP + program.

In addition to the Chair of Organic Chemistry, the Chair of Proteomics and Bioanalytics, and Radiochemistry Munich of the TUM, various working groups of the Helmholtz Center for Infection Research, the German Center for Infection Research, the German Cancer Research Center (DKFZ), Temple University (Philadelphia, USA), and Emory University (Atlanta, USA) participated in the research. Stephan Sieber is also scientifically associated with the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), an HZI site in cooperation with the University of Saarland, and the Institute for Advanced Study of the TUM.

Publication:

Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms

Philipp Le, Elena Kunold, Robert Macsics, Katharina Rox, Megan C. Jennings, Ilke M. Ugur, Maria Reinecke, Diego Chaves-Moreno, Mathias W. Hackl, Christian Fetzer, Franziska A. M. Mandl, Johannes Lehmann, Vadim S. Korotkov, Stephan M. Hacker, Bernhard Kuster, Iris Antes, Dietmar Pieper, Manfred Rohde, William M. Wuest, Eva Medina, Stephan A. Sieber

Nature Chemistry, Dec. 16, 2019 – DOI: 10.1038/s41557-019-0378-7

Media Contact
Dr. Andreas Battenberg
[email protected]
49-892-891-0510

Related Journal Article

http://dx.doi.org/10.1038/s41557-019-0378-7

Tags: BacteriologyBiochemistryBiologyCell BiologyChemistry/Physics/Materials SciencesInfectious/Emerging DiseasesMedicine/HealthMicrobiologyPharmaceutical ChemistryPharmaceutical Sciences
Share12Tweet8Share2ShareShareShare2

Related Posts

New Study Reveals How Online Language Patterns Could Indicate Self-Harm Risk

New Study Reveals How Online Language Patterns Could Indicate Self-Harm Risk

August 7, 2025
HM-TARGET: Personalized Real-Time Hemodynamic Targets Unveiled

HM-TARGET: Personalized Real-Time Hemodynamic Targets Unveiled

August 7, 2025

National Study Advocates for Expanded Vaccine Screening in Emergency Departments

August 7, 2025

Early-Life Famine Exposure, Obesity, and Testosterone Links

August 7, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Neuropsychiatric Risks Linked to COVID-19 Revealed

    76 shares
    Share 30 Tweet 19
  • Overlooked Dangers: Debunking Common Myths About Skin Cancer Risk in the U.S.

    61 shares
    Share 24 Tweet 15
  • Modified DASH Diet Reduces Blood Sugar Levels in Adults with Type 2 Diabetes, Clinical Trial Finds

    50 shares
    Share 20 Tweet 13
  • Predicting Colorectal Cancer Using Lifestyle Factors

    46 shares
    Share 18 Tweet 12

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Cutting-Edge Discoveries from MD Anderson: Research Highlights of August 7, 2025

Smart Deep Learning for Li-Ion Battery Health Prediction

Reevaluating Bipartite Patella: An Overlooked Ossicle

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.