• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Wednesday, August 27, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Ebola is a master of disguise

Bioengineer by Bioengineer
February 11, 2021
in Health
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Faculty of Medicine team from University of Ottawa have discovered a druggable pathway the virus uses to trick its way into our organs

IMAGE

Credit: University of Ottawa

It was once thought that Ebola and related filoviruses were more or less contained to Central Africa. After a West African outbreak and the discovery of Reston ebolavirus in the Philippines, cuevavirus in Spain and various bat filoviruses in China, researchers now understand that this viral family–causing hemorrhagic fevers with up to 90% case fatality rates–has been widespread around the world for millions of years.

Our defenses against it are more embryonic, and though we have a vaccine against one species of Ebola and some therapeutic antibodies on the horizon, both have production or distribution issues. What doctors have been hoping for is a regular drug that can treat Ebola as soon as it rears its terrifying head. A study published today in the journal PLOS Pathogens, identifies a pathway that all filoviruses use to gain entry into our cells–and shows how they can be stopped in their tracks by at least one FDA-approved drug.

Ebola is so pernicious because it pulls a fast one on the body, disguising itself as a dying cell.

“It’s cloaking itself in a lipid that is normally not exposed at the surface of a cell. It’s only exposed when the cell is undergoing apoptosis,” says Dr. Marceline Côté, an associate professor in the department of Biochemistry, Microbiology and Immunology, Canada Research Chair in Molecular Virology and Antiviral Therapeutics and the primary investigator on this study. Dr. Côté is a leading global expert on how viruses get into us, an understanding that is key to any effort to keep them out.

The malingering virus is then taken up by immune system cells that unwittingly carry the virus to other parts of the body, disseminating the infection. Virtually all organs become active sites of replication, and the result is a vicious, multi-system disease. Once it tricks its way into the cell, the virus needs to find a specific receptor that serves as the lock for its glycoprotein key, kicking off the process that will allow it to multiply. A drug that prevents it from any one step in turning that key could defeat the disease.

Dr. Côté’s team, in particular PhD student Corina Stewart, tested a library of drugs against a virus in cell cultures. It’s not safe to work with a replicating Ebola virus in a regular lab, so the uOttawa team used a surrogate system.

“We use a safe virus disguised as an Ebola virus. They will enter just the same way as an Ebola virus, but actually the inside core when they uncoat is all safe stuff,” says Dr. Coté. “It’s murine leukemia virus or engineered retroviruses, so nothing to worry about.”

Once they found a collection of drugs that seemed to work, they passed the data to collaborator Dr. Darwyn Kobasa at the National Microbiology Laboratory in Winnipeg, where a biosafety level 4 rating allows researchers to handle the bona fide virus. Dr. Kobasa confirmed that a small number of cancer chemotherapy drugs were effective in preventing Ebola from gaining a foothold in the cells.

Though these types of drugs can be tough on the body, an Ebola infection carries a high risk of death. What’s more, the infection doesn’t last long, so any unpleasant treatment can be similarly brief.

Knowing which drugs worked against Ebola also tells the team more about how the virus gets in. In particular, this study shows that Ebola virus has evolved ways to be active in its invasion of a cell. Previously, it was thought that viral entry was left mostly up to chance, with many particles being left behind while a random few were taken up into the cell. Dr. Côté’s study shows the virus has evolved to get in very efficiently, rather than just going along for the ride.

“They are not passive passengers,” says Dr. Côté. “They have their hands on the steering wheel.”

###

Media Contact
Paul Logothetis
[email protected]

Original Source

https://media.uottawa.ca/news/ebola-master-disguise

Related Journal Article

http://dx.doi.org/10.1371/journal.ppat.1009275

Tags: BiologyCell BiologyEpidemiologyImmunology/Allergies/AsthmaInfectious/Emerging DiseasesMicrobiologyParasitologyVirology
Share12Tweet8Share2ShareShareShare2

Related Posts

Exploring Gen Z Nurses’ Workplace Expectations and Preferences

August 27, 2025

Thioester-Driven RNA Aminoacylation Enables Peptide Synthesis

August 27, 2025

Exploring Frailty in Lung Transplantation: A Multidimensional Perspective

August 27, 2025

Polycystic Ovary Syndrome Affects Atherogenic Plasma Index

August 27, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    149 shares
    Share 60 Tweet 37
  • Molecules in Focus: Capturing the Timeless Dance of Particles

    142 shares
    Share 57 Tweet 36
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    115 shares
    Share 46 Tweet 29
  • Neuropsychiatric Risks Linked to COVID-19 Revealed

    82 shares
    Share 33 Tweet 21

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Exploring Gen Z Nurses’ Workplace Expectations and Preferences

New Optical Imaging Technique Promises Earlier Detection of Colorectal Cancer

Thioester-Driven RNA Aminoacylation Enables Peptide Synthesis

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.