• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Thursday, May 19, 2022
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

Dr. Sakamoto explains signaling pathways in the pathogenesis of diamond blackfan anemia

Bioengineer by Bioengineer
December 16, 2016
in Science News
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Credit: Stanford University

Diamond Blackfan Anemia (DBA) is a condition that is characterized by a failure of the bone marrow to produce red blood cells, congenital abnormalities, and a predisposition to cancer. Current treatment options, including steroid treatments and chronic transfusions, can lead to significant morbidity. Therefore, investigation into molecular mechanisms that drive DBA is critical to saving the lives of patients suffering from this disease.

DBA is caused by a deficiency of some ribosomal proteins to properly process pre-ribosomal ribonucleic acid (RNA), which is ultimately important for the translation of the genome into functional proteins. While it is known that p53, an important DNA repair protein, mediates many facets of DBA, its mechanism has not, until now, been well understood. With support from a Bone Marrow Failure Research Program FY12 Idea Award, Dr. Kathleen Sakamoto and her team at Stanford University has identified that a deficiency in RPS19, the most commonly mutated ribosomal protein in DBA patients, leads to the upregulation and activation of the p53 pathway. Furthermore, they have identified that a target of p53, microRNA34A, is responsible for decreased red blood cell formation.

In a recently published article in Disease Models & Mechanisms, Dr. Sakamoto's team used a zebrafish model of DBA with RPS19 and RPL11 insufficiency to further characterize the link between defects in ribosome biogenesis, nucleotide metabolism, and the p53 pathway in DBA. The RPS19-deficient zebrafish showed a decrease in proliferation, enhanced activation of the ATR/ATM-CHK1/CHK2/p53 DNA damage pathway, an imbalanced pool of nucleotides, ATP depletion, and AMPK activation. These findings are all hallmarks of cellular energy crisis,DNA replication stress, and thus enhanced DNA repair. When treating zebrafish with exogenous nucleosides, a decrease in the activation of p53 and AMPK was observed. As blood cells are highly dependent on salvage pathways for the production of nucleotides and are therefore vulnerable to a stressed metabolism, red blood cells in DBA patients may benefit from exogenous nucleosides. Nucleoside supplements are known to be very safe and are even included in many infant formulas. This form of supplementation may be beneficial, not only in patients with DBA, but also for other conditions that involve the activation of the DNA damage response, such as radiation exposure. Furthermore, treatment of the RP-deficient zebrafish with inhibitors of various cell cycle checkpoint kinases decreased p53 upregulation and apoptosis while resulting in an improvement of hematopoiesis. Therefore drugs that work to decrease DNA damage or help increase DNA repair could be effective for the treatment of DBA.

The results from this research have shed light on a previously undiscovered link between the well-studied p53 pathway and the lesser known pathways associated with ribosome biogenesis and nucleotide metabolism in DBA. Uncovering this link may provide several avenues for new treatment options for patients suffering from DBA and its current treatment regimens.

###

Media Contact

Gail Whitehead
[email protected]
301-619-7783

http://cdmrp.army.mil

############

Story Source: Materials provided by Scienmag

Share12Tweet7Share2ShareShareShare1

Related Posts

A revolution in recycling

Recycling more precious metals from nuclear and electronic waste using the Picasso pigment, Prussian blue

May 19, 2022
Tom70-based transcriptional regulation of mitochondrial biogenesis and aging

Buck Scientist uncovers clues to aging in mitochondria

May 18, 2022

Scripps Research awarded $67 million by NIH to lead new Pandemic Preparedness Center

May 18, 2022

NIAID announces antiviral drug development awards

May 18, 2022
Please login to join discussion

POPULAR NEWS

  • Weybourne Atmospheric Observatory

    Breakthrough in estimating fossil fuel CO2 emissions

    46 shares
    Share 18 Tweet 12
  • Hidden benefit: Facemasks may reduce severity of COVID-19 and pressure on health systems, researchers find

    44 shares
    Share 18 Tweet 11
  • Discovery of the one-way superconductor, thought to be impossible

    43 shares
    Share 17 Tweet 11
  • Sweet discovery could drive down inflammation, cancers and viruses

    43 shares
    Share 17 Tweet 11

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

University of WashingtonVirologyVehiclesZoology/Veterinary ScienceVaccinesUrogenital SystemUrbanizationWeaponryVirusVaccineViolence/CriminalsWeather/Storms

Recent Posts

  • Recycling more precious metals from nuclear and electronic waste using the Picasso pigment, Prussian blue
  • Buck Scientist uncovers clues to aging in mitochondria
  • Scripps Research awarded $67 million by NIH to lead new Pandemic Preparedness Center
  • NIAID announces antiviral drug development awards
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Posting....