• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, September 26, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

Development of a multidimensional vibrational circular dichroism system with a quantum cascade laser

Bioengineer by Bioengineer
March 2, 2021
in Science News
Reading Time: 2 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

A system with a scanning function was applied for peptides containing D-amino acid residues

IMAGE

Credit: Hisako Sato, Ehime University

Currently, the roles of free D-amino acids and D-amino acid residues in proteins are garnering extensive attention in biological fields such as molecular biology, physiology, microbiology, and pathophysiology. Because it is crucial to analyze these materials rapidly and accurately, many methods have been employed. However, samples for measurement are currently limited to solutions containing target molecules in the pure form. Hence, there is need for an analytical method for the in situ measurement of biological samples placed on a solid support.

We report the construction of a multidimensional vibrational circular dichroism spectroscopy (MutilD-VCD) for dipeptides and amino acids with D-amino acid residues in amides I and II regions. It was a challenging goal because of the disturbance of the bending vibration of water. VCD spectroscopy is a chiroptical spectroscopy with unique characteristics. In the present study, a quantum cascade laser (QCL) was installed as an infrared source to achieve high intensity and narrow focusing. A MultiD-VCD system with three coordinates (wavenumber, VCD intensity, and position) was developed. The instrument was switchable to a concurrent FT-VCD (Fourier Transform Vibrational Circular Dichroism) system. A scanning device was installed to move an attached motorized stage in two dimensions.

Results indicated that the instrument could obtain the VCD spectrum of dipeptides, including D-amino acid, in an aqueous solution under interference caused by a water medium. Moreover, it achieved the two-dimensional patterning of the distribution and discrimination of chiral components (L-Ala and D-Ser) within a KBr pellet. Our final goal is to identify the location of D-amino acid residue in the aggregates of proteins, such as amyloids, and to clarify how the chiral inversion of a single amino acid residue in a protein affects its biological functions. An improved spatial resolution may benefit the basic fields of analytical and medical sciences as well as the practical field of chiral component analysis in drugs in the future.

###

Media Contact
Public Relations Division
[email protected]

Original Source

https://pubs.acs.org/doi/full/10.1021/acs.analchem.0c02990

Related Journal Article

http://dx.doi.org/10.1021/acs.analchem.0c02990

Tags: BiochemistryChemistry/Physics/Materials SciencesMaterialsNanotechnology/MicromachinesPharmaceutical Sciences
Share12Tweet8Share2ShareShareShare2

Related Posts

Investigating Firearm-Related Homicides Among Children and Adolescents in Domestic Settings

Investigating Firearm-Related Homicides Among Children and Adolescents in Domestic Settings

September 26, 2025

Volumetric Analysis Reveals Quantitative Impact of Hyaluronic Acid Filler Injections

September 26, 2025

Telestroke Patients: Improved Access to Treatment, Yet Facing Increased Delays

September 26, 2025

Deep Learning Revolutionizes Multiscale Design of Porous Electrodes in Flow Cells

September 26, 2025
Please login to join discussion

POPULAR NEWS

  • New Study Reveals the Science Behind Exercise and Weight Loss

    New Study Reveals the Science Behind Exercise and Weight Loss

    79 shares
    Share 32 Tweet 20
  • Physicists Develop Visible Time Crystal for the First Time

    72 shares
    Share 29 Tweet 18
  • Scientists Discover and Synthesize Active Compound in Magic Mushrooms Again

    55 shares
    Share 22 Tweet 14
  • Tailored Gene-Editing Technology Emerges as a Promising Treatment for Fatal Pediatric Diseases

    51 shares
    Share 20 Tweet 13

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Investigating Firearm-Related Homicides Among Children and Adolescents in Domestic Settings

Volumetric Analysis Reveals Quantitative Impact of Hyaluronic Acid Filler Injections

Telestroke Patients: Improved Access to Treatment, Yet Facing Increased Delays

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.