TORONTO, Sept. 1, 2016–Parts of Africa and the Asia-Pacific region may be vulnerable to outbreaks of the Zika virus, including some of the world's most populous countries and many with limited resources to identify and respond to the mosquito-borne disease, a new study says.
The study, published online today in The Lancet Infectious Diseases, said India, China, the Philippines, Indonesia, Nigeria, Vietnam, Pakistan, and Bangladesh may be at greatest risk of local outbreaks. These countries receive a combination of high volumes of travelers from Zika-affected areas, have mosquitos capable of transmitting Zika virus, climate conditions conducive to local spread, and limited health resources.
Study author Dr. Kamran Khan of St. Michael's Hospital in Toronto said that identifying where and when populations would be most susceptible to local transmission of Zika virus could help inform public health decisions about the use of finite resources.
"An estimated 2.6 billion people live in areas of Africa and Asia-Pacific where local Zika virus transmission is possible," said Dr. Khan. "The potential for epidemics in those regions is particularly concerning given that the vast numbers of people who could be exposed to Zika virus are living in environments where health and human resources to prevent, detect, and respond to outbreaks are limited."
The research team, which included scientists from Toronto General Hospital, the London School of Hygiene & Tropical Medicine and Oxford University, analyzed airline passenger traffic data from 689 cities with commercial airports in the Americas. They then mapped the monthly destinations and volumes of travellers arriving into Africa and Asia-Pacific to identify countries at greatest risk of Zika virus importation across seasons. Health expenditure per capita was used as a proxy of a country's capacity to detect and effectively respond to a possible Zika virus outbreak.
Countries with populations at risk for Zika virus importation and subsequent spread include India (67,422 travellers arriving per year; 1.2 billion residents in potential Zika transmission areas), China (238,415 travellers; 242 million residents), Indonesia (13,865 travellers; 197 million residents), the Philippines (35,635 travellers; 70 million residents) and Thailand (29241 travellers; 59 million residents).
Dr. Isaac Bogoch, another author of the study and an infectious disease specialist at University Health Network's Toronto General Hospital, said the health consequences of Zika in Africa and Asia-Pacific will depend not just on local ability to diagnose and respond to a possible outbreak, but also on levels of existing immunity to Zika virus. Even though Zika virus was first identified in Africa, and sporadic cases have been reported in both Africa and Asia-Pacific, little is known about whether the Asian strain of the virus (now circulating in the Americas) will affect individuals differently if they have previously been infected with the African strain.
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This study received funding from the Canadian Institutes of Health Research.
About St. Michael's Hospital
St. Michael's Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future health care professionals in more than 23 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, and care of the homeless are among the Hospital's recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Centre, which make up the Li Ka Shing Knowledge Institute, research and education at St. Michael's Hospital are recognized and make an impact around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto.
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