Cancer
A Few Random Mutations Turn Simple RNA Droplets into Moving, Cargo-Carrying Synthetic Cells
Researchers at Heidelberg University showed that a mutation rate of around three percent transforms simple RNA droplets into cell-like structures...
KRAS-mutant tumors flood themselves with adenosine to blind immune cells
Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that...
Fat-Derived Stem Cells Transformed Into Lymphatic Vessels in Lab Breakthrough
Researchers have developed a three-stage protocol that reliably converts adipose-derived mesenchymal stem cells into functional lymphatic endothelial precursor cells, which...
Blood Test Clue: Monocyte Recovery During Glioblastoma Treatment Predicts Longer Survival
A new study finds that patients with IDH-wildtype glioblastoma whose circulating monocyte counts are preserved during chemoradiotherapy survive substantially longer,...
Deuterium swap turns one molecule into a brighter, tougher cancer fighter
Researchers at Shenzhen University show that replacing hydrogen with deuterium in a near-infrared fluorescent molecule simultaneously improves imaging brightness, therapeutic...
Blocking FGFR Signaling Supercharges Immunotherapy in Hard-to-Treat Colorectal Cancer
New research shows that inhibiting the FGFR signaling pathway reduces T cell exhaustion and repolarizes macrophages, significantly enhancing PD-1 blockade...
Nearly One in Five Cancer Therapy Hospitalizations Could Have Been Prevented, Study Finds
A retrospective Japanese hospital study found that 18.6 percent of unplanned admissions caused by cancer drug side effects were potentially...
TEAD transcription factors emerge as a new frontier in cancer therapy
A new review in Molecular Cancer details how the TEAD family of transcription factors drives cancer, the drugs now targeting...
The Methylation Test That Decides Brain Cancer Treatment Faces a Reckoning
A new Mayo Clinic review in the Journal of Neuro-Oncology examines how MGMT promoter methylation guides brain tumor treatment, why...
Cancer Gene Mutations Awaken the Immune System in Early Oral Cancer
Researchers at Tokushima University found that combined TP53 and CDKN2A mutations activate cGAS–STING-mediated antitumor immunity, delaying progression to invasive oral...
Cancer Patients in Rural South Africa Carry a Heavy Burden of Fear, Pain and Poverty
A survey of 207 oncology patients in rural Limpopo Province reveals near-universal pain, fear of death and financial hardship, prompting...
When Tumors Hide Their Flags, Natural Killer Cells May Take Over Against Colorectal Cancer
Two patients with microsatellite-unstable metastatic colorectal cancer and markedly reduced HLA-I expression achieved durable responses to pembrolizumab, suggesting that NK...
Inside the Integrative Oncology Clinic: Who Seeks Complementary Cancer Care and What They Receive
A prospective French study of fifty patients at the Léon Bérard Cancer Center reveals who attends integrative oncology consultations, what...
Cholesterol Plummets in Oral Cancer Patients, Huge Meta-Analysis Finds
A new meta-analysis of 25 studies finds that oral cancer patients show significantly lower total cholesterol, triglycerides, HDL, LDL, and...
Tiny Antennae on Bile Duct Cells Emerge as Master Sensors of Liver Health and Disease
A new review in Nature Reviews Gastroenterology & Hepatology explains how cholangiocyte primary cilia sense bile flow, chemistry and tonicity...
Weekly MRI Reveals Radiation’s Early Fingerprint on the Brain’s Memory Hub
Weekly diffusion MRI during six weeks of partial-brain radiation therapy for high-grade glioma reveals a progressive, dose-dependent increase in hippocampal...
Triple Drug Combo for Advanced Breast Cancer Hits Targets but Falls Short of Standard Care
A phase Ib/II trial testing famitinib added to dalpiciclib and fulvestrant in HR-positive, HER2-negative advanced breast cancer met early response...
From Dish to Living Brain: How Lab-Grown Human Microglia Are Rewriting Neuroimmune Research
A new review charts how stem cell-derived human microglia, brain organoids and chimeric mice are overcoming the genetic and environmental...
When Healthy Cells Merge: Fusion Events Trigger Genome Chaos That May Ignite Cancer
New research shows that spontaneous fusion between non-malignant breast epithelial cells triggers catastrophic genomic instability, ploidy reduction and EMT-like traits,...
Immune Checkpoint Inhibitor Combos Ranked for Liver Cancer in Major Analysis
A network meta-analysis of eight randomized trials finds that immune checkpoint inhibitors combined with anti-VEGF therapy outperform other immunotherapy combinations...
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