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Home NEWS Science News Immunology

Building an AI to predict if you carry a killer on your skin

Bioengineer by Bioengineer
December 16, 2018
in Immunology
Reading Time: 2 mins read
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Staphylococcus epidermidis is an ubiquitous colonizer of healthy human skin, but it is also a notorious source of serious nosocomial infections with indwelling devices and surgical procedures such as hip replacements.

It has not been known whether all members of the S. epidermidis population colonizing the skin asymptomatically are capable of causing such infections, or if some of them have a heightened tendency to do so when they enter either the bloodstream or a deep tissue.

FCAI scientists Johan Pensar and Jukka Corander from the Aalto-University and the University of Helsinki, joined a team of microbiologists and geneticists to unravel this mystery. By combining large-scale population genomics and in vitro measurements of immunologically relevant features of these bacteria, they were able to use machine learning to successfully predict the risk of developing a serious, and possibly life-threatening infection from the genomic features of a bacterial isolate.

This opens the door for future technology where high-risk genotypes are identified proactively when a person is to undergo a surgical procedure, which has high potential to reduce the burden of nosocomial infections caused by S. epidermidis.

###

Reference:

Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis,

Nature Communications volume 9, Article number: 5034 (2018) https://www.nature.com/articles/s41467-018-07368-7

More information:

Jukka Corander, University of Helsinki, +358 50 415 5294, [email protected]

Media Contact
Riitta-Leena Inki
[email protected]
358-504-485-770

Related Journal Article

https://www.helsinki.fi/en/news/science-news/safe-hip-replacements-building-an-ai-to-predict-if-you-carry-a-killer-on-your-skin
http://dx.doi.org/10.1038/s41467-018-07368-7

Tags: Algorithms/ModelsBacteriologyInfectious/Emerging DiseasesMathematics/StatisticsRobotry/Artificial IntelligenceSurgery
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