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Home NEWS Science News Health

Benefiting from the national gene vector biorepository

Bioengineer by Bioengineer
March 27, 2020
in Health
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Credit: Mary Ann Liebert, Inc., publishers


New Rochelle, NY, March 26, 2020–Gene therapy investigators can greatly benefit from the resources and services provided by the National Gene Vector Biorepository (NGVB), housed at the Indiana University School of Medicine. These include 93 unique reagents, a searchable database of animal safety studies, and Replication Competent Virus Testing, as detailed in an article published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Human Gene Therapy website through April, 26 2020.

“The National Gene Biorepository: Eleven Years of Providing Resources to the Gene Therapy Community” was coauthored by Kenneth Cornetta, Lorraine Matheson, Ryan Long, and Lisa Duffy, Indiana University School of Medicine, Indianapolis.

The Reagent Repository has distributed more than 1,000 reagents to nearly 400 investigators. Included in the repository are reagents such as plasmids for adeno-associated virus (AAV) gene transfer and cell lines used to manufacture retroviral, lentiviral, adenoviral, and AAV gene therapies. Also included in the NGVB’s resources and services is the Pharmacology and Toxicology (Pharm/Tox studies) Good Laboratory Practice (GLP) archive for storing samples from pharm/tox studies.

The authors describe three main rationale for offering NGVB services: decreasing the risk of non-compliance with FDA requirements; addressing the disconnect between clinical trial grant funding periods and extended post-trial monitoring requirements; and reducing costs.

“The NGVB resource is one of the key elements in the NIH strategy to enable academic researchers to pursue early phase clinical trials of their gene therapies with or without industry involvement,” says Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Medical School, Worcester, MA. “Without such resources, the cost of these services would otherwise be prohibitive for academic scientists, and their work would perish in the proverbial ‘valley of death’

###

About the Journal

Human Gene Therapy, the Official Journal of the European Society of Gene and Cell Therapy and eight other international gene therapy societies, was the first peer-reviewed journal in the field and provides all-inclusive access to the critical pillars of human gene therapy: research, methods, and clinical applications. The Journal is led by Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Medical School, and an esteemed international editorial board. Human Gene Therapy is available in print and online. Complete tables of contents and a sample issue are available on the Human Gene Therapy website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Nucleic Acid Therapeutics, Tissue Engineering, Stem Cells and Development, and Cellular Reprogramming. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 90 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Media Contact
Kathryn Ryan
[email protected]
914-740-2250

Original Source

https://home.liebertpub.com/news/benefiting-from-the-national-gene-vector-biorepository/3675

Related Journal Article

http://dx.doi.org/10.1089/hum.2019.317

Tags: Cell BiologyDisease in the Developing WorldEnvironmental HealthGene TherapyInfectious/Emerging DiseasesMedicine/Health
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