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Home NEWS Science News Technology

Bacterial Culprit Behind Lake Erie’s Lethal Toxin Identified in U-M Research

Bioengineer by Bioengineer
April 30, 2025
in Technology
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In Lake Erie, one of the five Great Lakes of North America, a concerning ecological phenomenon emerges every summer: harmful algal blooms. These blooms are primarily composed of cyanobacteria, also known as blue-green algae, which can proliferate rapidly in warm water. The implications of these algal blooms extend beyond simply disfiguring water bodies; they pose significant threats to both wildlife and human health by producing a variety of toxins. Of particular concern is the recent identification of Dolichospermum, a type of cyanobacteria found in Lake Erie, as a primary producer of these harmful toxins.

The proliferation of harmful algal blooms, or HABs, varies chronically in composition and toxicity. Different strains of cyanobacteria can release a range of toxins, each with varying biological impacts. The recent breakthrough by researchers at the University of Michigan underscores a crucial element of ecological study: identifying the specific organisms responsible for the production of these toxins can greatly enhance our capabilities to monitor and mitigate the effects of harmful blooms. Understanding which cyanobacteria generate which toxins is a critical step in formulating effective management strategies.

A significant incident occurred in 2014, during which a large algal bloom released microcystin, a potent toxin that severely threatened Toledo’s drinking water supply. This event exemplifies the urgent need for a better understanding of the organisms involved in toxin production. Earlier, in 2007, Lake Erie faced another alarming scenario when scientists documented the presence of saxitoxin—a neurotoxin known for its high potency—but struggled to pinpoint its specific source. The identification of Dolichospermum as the culprit for saxitoxin production brings much-needed clarity to scientists navigating the complexities of algal blooms.

Gregory Dick, a professor of earth and environmental sciences and a key researcher in the study, emphasizes the importance of identifying the organisms behind toxin production. Knowing the specific cyanobacteria responsible for these harmful outputs assists in elucidating the environmental conditions that foster their success. It is essential to understand what ecological conditions lead to heightened toxin production, as this information can inform policy decisions and management guidelines aimed at curbing the impacts of harmful algal blooms.

To pinpoint Dolichospermum in Lake Erie, researchers collected samples from harmful algal blooms over time. Utilizing a high-throughput DNA sequencing technique known as “shotgun” sequencing, they conducted genetic analyses on collected water samples. This method allows for the sequencing of all DNA within a sample, which the research team then assembled into complete genomic sequences. By examining these genomic assemblies, they identified genes responsible for encoding the toxin saxitoxin.

The researchers discovered multiple strains of Dolichospermum in Lake Erie; however, only specific strains were involved in saxitoxin production. Despite the identification of these toxic-producing strains, the uncertainty regarding why certain strains produce saxitoxin while others do not remains. Understanding the myriad factors that influence saxitoxin production is quintessential for effectively addressing the risks posed by these toxic blooms.

In addition to identifying and characterizing the producing organism, the research team examined environmental variables to determine how they influence saxitoxin production. They sampled different locations throughout Lake Erie across various seasons, measuring levels of the saxitoxin-associated gene in their findings. One clear pattern emerged: higher temperatures were often correlated with increased gene abundance related to saxitoxin production.

This discovery is particularly pertinent in light of global climate change, which is unequivocally leading to warming waters in many lakes. As Dr. Den Uyl notes, understanding how rising temperatures affect biological communities, including the dynamics of harmful cyanobacterial blooms, becomes increasingly critical. Given the ongoing changes to Lake Erie and other water bodies, researchers must remain vigilant in monitoring these shifts.

Another significant finding revealed that areas with elevated concentrations of ammonium tended to show a decrease in the presence of the saxitoxin gene. This leads researchers to speculate that Dolichospermum possesses a distinct ecological advantage: the ability to utilize dinitrogen gas, abundant in the atmosphere, for nitrogen fixation. This capability is relatively rare among aquatic organisms, providing Dolichospermum with a competitive edge under certain environmental conditions.

Dr. Dick elaborates on this unique adaptation, explaining that understanding the full genome of Dolichospermum provides researchers with a theoretical framework for the organism’s potential capabilities. The genome serves as a blueprint, providing insights into various biological processes. The ability of Dolichospermum to obtain and utilize nitrogen from the atmosphere may indicate a remarkable adaptation that can significantly influence its growth and toxin-producing capacity.

The research team’s longitudinal study of saxitoxin production in Lake Erie has been underway for nearly a decade. However, this time frame may not suffice to confidently predict whether saxitoxin production will escalate alongside rising water temperatures. As the researchers continue to analyze the correlation between temperature and toxin production, they aim to broaden their understanding of current and future trends.

Now armed with knowledge of the specific organisms producing saxitoxin, scientists express optimism for improved monitoring strategies. According to Dr. Dick, establishing a sustained observation of toxin-producing organisms will facilitate informed assessments of toxic gene abundance over time. While the current findings raise concerns about potential correlations between temperature and toxin prevalence, further study will be essential to making definitive conclusions.

As the research unfolds, further investigations will explore best practices for managing harmful algal blooms in the context of changing environmental conditions. By continuing to study the dynamics of cyanobacterial populations and their toxin-producing capabilities, scientists hope to establish a proactive response to mitigate the risks posed by algal blooms.

The findings are documented in the journal Environmental Science & Technology, highlighting the need for interdisciplinary collaboration among ecologists, hydrologists, and environmental policymakers to address these pressing ecological challenges. The collaboration between researchers and future studies will undoubtedly pave the way for more effective strategies in safeguarding public health and enhancing water quality in Lake Erie and beyond.

Subject of Research: Identification and characterization of saxitoxin-producing cyanobacteria in Lake Erie
Article Title: Genomic Identification and Characterization of Saxitoxin Producing Cyanobacteria in Western Lake Erie Harmful Algal Blooms
News Publication Date: Not specified
Web References: DOI: 10.1021/acs.est.4c10888
References: Environmental Science & Technology
Image Credits: Not specified

Keywords

Tags: blue-green algae health riskscyanobacteria toxin producersDolichospermum cyanobacteriaecological impact of algal bloomshuman health implications of water toxinsLake Erie harmful algal bloomsmicrocystin toxicity effectsMonitoring harmful algal bloomsstrategies for algal bloom managementsummer algal bloom proliferationUniversity of Michigan researchwildlife threats from toxins

Tags: cyanobacterial toxin geneticsDolichospermum cyanobacteriaenvironmental health risksLake Erie harmful algal bloomssaxitoxin production
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