https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/13/issue/12
Credit: APSB
https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/13/issue/12
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Articles of interest in this issue include:
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma by Yingqiang Liu, Zhengsheng Zhan, Zhuang Kang et al. (https://doi.org/10.1016/j.apsb.2023.09.009). SYHA1813 exerts anti-tumor effects by simultaneously inhibiting angiogenesis and affecting tumor-associated macrophages, and shows the therapeutic potential of glioma by efficiently crossing the blood–brain barrier.
Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection by Xintong Zhao, Jing Feng, Jie Zhang et al. (https://doi.org/10.1016/j.apsb.2023.08.030). A novel pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection with excellent pharmacological activity and druggability was discovered by the structural modifications of the AZD5099 which was withdrawn from clinical trials.
Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration by Qiaozi Wang, Yanan Song, Jinfeng Gao et al. (https://doi.org/10.1016/j.apsb.2023.08.021). Hybrid neutrophil-mimic nanoparticle NM@miR could realize absorption of proinflammatory cytokines and delivery of proliferative microRNA together, which holds huge potential for the regenerative treatment of cardiac ischemic diseases.
Other articles include:
Review Articles
Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays
Yanping Wang, Weihong Du, Xiaoyan Hu, Xin Yu, … Wei Wang
Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy
Jing Ye, Jin Zhang, Yanghui Zhu, Lian Wang, … Gu He
Emerging drug design strategies in anti-influenza drug discovery
Chuanfeng Liu, Lide Hu, Guanyu Dong, Ying Zhang, … Peng Zhan
Original Articles
ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells
Mingjin Wang, Weida Wang, Shen You, Zhenyan Hou, … Jing Jin
Non-canonical STING–PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response
Xuesong Li, Xiang Chen, Longbin Zheng, Minghong Chen, … Hongshan Chen
Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming
Shixin Duan, Xinyi Lou, Shiyi Chen, Hongchao Jiang, … Feng
Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner
Kaikai Zhang, Lijian Chen, Jianzheng Yang, Jiali Liu, … Qi Wang
TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage
Wenjun Yu, Haixia Xu, Zhe Sun, Yuxin Du, … Yingmei Zhang
ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17
Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, … Xiaowei Nie
Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly attenuated vesicular stomatitis virus vector (VSVMT) in golden syrian hamster
Yong Ke, En Zhang, Jianming Guo, Xiaoxiao Zhang, … Baohong Zhang
Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis
Wenjing Yu, Yuehuai Hu, Zhiping Liu, Kaiteng Guo, … Jing Lu
A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors
Youchao Deng, Xiaosheng Song, Iredia D. Iyamu, Aiping Dong, … Rong Huang
Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility
Li-Min Zhao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
Feifei Fang, Yang Dai, Hao Wang, Yinchun Ji, … Yu Zhou
Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer
Jia-Luo Huang, Xue-Long Yan, Dong Huang, Lu Gan, … Sheng Yin
Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer
Yubo Wang, Jian Min, Xiangping Deng, Tian Feng, … Hai-Bing Zhou
Development of exosome membrane materials-fused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent
Yongho Jang, Jeehun Park, Pilsu Kim, Eun-Joo Park, … Hyuncheol Kim
Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils
Peng Hua, Ruifeng Liang, Yanbei Tu, Yuying Yin, … Meiwan Chen
Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity
Huaqing Jing, Yingzi Ren, Yue Zhou, Min Xu, … Nan Li
Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy
Xiaodi Liu, Qi Zhang, Yixia Liang, Shiyu Xiong, … Baoming Luo
Purpurolide C-based microneedle promotes macrophage-mediated diabetic wound healing via inhibiting TLR4-MD2 dimerization and MYD88 phosphorylation
Yitong Liu, Guiyang Xia, Yingyi Chen, Huan Xia, … Yi Liu
Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy
Lina Guo, Jinsong Ding, Wenhu Zhou
An injectable signal-amplifying device elicits a specific immune response against malignant glioblastoma
Qiujun Qiu, Sunhui Chen, Huining He, Jixiang Chen, … Jianxin Wang
Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment
Yan Zhang, Haiyun Zhang, Faquan Zhao, Zhengping Jiang, … Qiangsong Wang
Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect
Feng Long, Yao Pan, Jinheng Li, Suinan Sha, … Ying Wang
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 15.9
Impact Factor: 14.907
JIF without self-citation: 13.885
ISSN 2211-3835
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