• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Saturday, June 21, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

The evolutionary secret of H. pylori to survive in the stomach

Bioengineer by Bioengineer
December 20, 2016
in Science News
Reading Time: 2 mins read
0
ADVERTISEMENT
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Professor Frédéric Veyrier's most recent research, in collaboration with the team of Professor Hilde De Reuse at the Institut Pasteur, has shed light on key genes essential to the pathogenesis of Helicobacter pylori bacterium, which causes gastric infections. Like other microorganisms, this pathogen underwent genetic modifications through the course of evolution that enabled it to adapt to its environment.

Nickel is in fact the evolutionary key that allows the pathogen to survive the very acid conditions of the stomach. This metal is a cofactor of two essential proteins, one of which is urease, an enzyme that neutralizes gastric acid. Therefore, to colonize the stomach, the pathogen needs an efficient nickel transport system. By examining the bacterium's entire genome, the research team identified a new nickel transporter that appears to be essential for the metal acquisition. Once inside the bacterial cell, nickel regulates the synthesis of urease, which in turn neutralizes the acid from the stomach. This gene, along with a number of other genes encoding proteins involved in nickel homeostasis, has been acquired a long time ago by the bacterium via horizontal gene transfer.

Metals are often key players during bacterial pathogenesis. It is the case for many other microorganisms, including pathogenic strains of Escherichia coli, in which iron plays a major role in its ability to infect the host. However, the genetic reshuffling leading to metal homeostasis modifications in Helicobacter pylori and allowing it to adapt to the gastric environment seems to be quite unique.

Further genetic studies should enable researchers to identify other genes that have been dropped or acquired through evolution, giving microorganisms the characteristics they need to colonize their hosts and cause disease. In a way, we can think of these genes as messengers from the past. This research work will be used to develop strategies for fighting these infections.

###

To find out more:

The most recent publication of Professor Veyrier and his team: Characterization in Helicobacter pylori of a Nickel Transporter Essential for Colonization that was Acquired during Evolution by Gastric Helicobacter Species, PLOS Pathogens, Dec. 6, 2016

Media Contact

Frédéric Veyrier
[email protected]
450-687-5010 x8831
@U_INRS

Accueil

############

Story Source: Materials provided by Scienmag

Share12Tweet7Share2ShareShareShare1

Related Posts

blank

Gasdermin E Drives Pyroptosis Resistance in Glioblastoma

June 21, 2025
blank

AI Diagnoses Vocal Cord Paralysis Severity

June 21, 2025

Humeral Rotation Impacts Rotator Cuff Mechanics

June 21, 2025

Racial Disparities Impact Neonatal Hypoxic-Ischemic Outcomes

June 21, 2025
Please login to join discussion

POPULAR NEWS

  • Green brake lights in the front could reduce accidents

    Study from TU Graz Reveals Front Brake Lights Could Drastically Diminish Road Accident Rates

    161 shares
    Share 64 Tweet 40
  • New Study Uncovers Unexpected Side Effects of High-Dose Radiation Therapy

    76 shares
    Share 30 Tweet 19
  • Pancreatic Cancer Vaccines Eradicate Disease in Preclinical Studies

    71 shares
    Share 28 Tweet 18
  • How Scientists Unraveled the Mystery Behind the Gigantic Size of Extinct Ground Sloths—and What Led to Their Demise

    65 shares
    Share 26 Tweet 16

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Gasdermin E Drives Pyroptosis Resistance in Glioblastoma

AI Diagnoses Vocal Cord Paralysis Severity

Humeral Rotation Impacts Rotator Cuff Mechanics

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.