• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Tuesday, September 23, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

Targeting legumain as a novel therapeutic strategy in cancers

Bioengineer by Bioengineer
January 3, 2017
in Science News
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Credit: Dr. Chun Wai Mai et al, Bentham Science Publishers

Legumain (LGMN), or asparaginyl endopeptidase, is a newly identified lysosomal cysteine protease. It was recently found to be over-expressed in tumour microenvironment , an enclosed environment that facilitates the interaction among the human solid tumours, tumour-associated endothelial and stromal cells, as well as in tumour-associated macrophages. These non-malignant cells support the growth of the tumours, metastasis and the survival of tumours. One of the identified key biomarkers driving the complexity of tumour microenvironment is LGMN. LGMN is a robust acidic cysteine endopeptidase with remarkably restricted specificity for hydrolysis of asparaginyl bonds.

LGMN is well conserved, having been reportedly preent in plants, invertebrate parasites, as well as in mammals. Mammalian LGMN processes the self and foreign antigens expressed by antigen presenting cells and proteolytically activates toll-like receptor, the innate immunity receptor. Since LGMN has been implicated in tumour development and can potentially be developed into both diagnostic and therapeutic markers. This review aims to relate the recent findings on the biology of LGMN in cancers, to the therapeutic advancements in targeting LGMN in human cancers.

LGMN may serve as both a potential oncogenic marker and a molecular target for treatment of cancer especially for personalized medicine. Although recent findings have shed light on the functional roles and expression patterns of LGMN, further investigations are still warranted to elucidate the exact role and underlying mechanism of action for LGMN in cancer. Recent discoveries have also demonstrated that targeting LGMN directly or utilizing LGMN as a prodrug activator are promising strategies for cancer management in the future. However, further research is necessary before such therapeutic strategies can be fully realized.

###

For more info, please visit https://benthamscience.com/journals/current-drug-targets/article/148446/

Reference: Mai, CW.; et al (2016). Targeting Legumain As a Novel Therapeutic Strategy in Cancers. Current Drug Targets., DOI: 10.2174/1389450117666161216125344 10.2174/1389450117666161216125344

Media Contact

Faizan ul Haq
[email protected]
@BenthamScienceP

http://benthamscience.com/

############

Story Source: Materials provided by Scienmag

Share12Tweet8Share2ShareShareShare2

Related Posts

Efficient Lithium/Sodium Iron Silicate Cathodes via Milling

Efficient Lithium/Sodium Iron Silicate Cathodes via Milling

September 23, 2025
Metal-Doped Prussian Blue Nanoparticles Enhance Battery Anodes

Metal-Doped Prussian Blue Nanoparticles Enhance Battery Anodes

September 23, 2025

How Federal Health Surveys Are Measuring Sexual Orientation, Gender Identity, and Differences in Sex Development

September 22, 2025

Gene Analysis Uncovers Metal Exposure in Synechococcus

September 22, 2025
Please login to join discussion

POPULAR NEWS

  • Physicists Develop Visible Time Crystal for the First Time

    Physicists Develop Visible Time Crystal for the First Time

    69 shares
    Share 28 Tweet 17
  • Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    156 shares
    Share 62 Tweet 39
  • Tailored Gene-Editing Technology Emerges as a Promising Treatment for Fatal Pediatric Diseases

    50 shares
    Share 20 Tweet 13
  • Scientists Achieve Ambient-Temperature Light-Induced Heterolytic Hydrogen Dissociation

    49 shares
    Share 20 Tweet 12

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Efficient Lithium/Sodium Iron Silicate Cathodes via Milling

Metal-Doped Prussian Blue Nanoparticles Enhance Battery Anodes

How Federal Health Surveys Are Measuring Sexual Orientation, Gender Identity, and Differences in Sex Development

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.