Fatty Acid Dysregulation Linked to Parkinson’s Disease Subtypes
A new review in Cellular and Molecular Neurobiology proposes that fatty acid dyshomeostasis, or fatty acidopathy, is a key metabolic ...
Tag: α-synuclein
Phosphorylation of 14-3-3γ Impairs Its Ability to Limit Alpha-Synuclein Aggregation
A new study reveals that Ser59 phosphorylation impairs the protective ability of 14-3-3γ against alpha-synuclein aggregation and reshapes its global ...
Tear Fluid α-Synuclein Shows Promise as Noninvasive Biomarker for Parkinson’s Disease
A pilot cross-sectional study found significantly elevated total α-synuclein in non-stimulated basal tears of Parkinson's disease patients, with moderate diagnostic ...
High-altitude exposure linked to α-synuclein burden and mouse pathology
A multi-method study linked chronic high-altitude exposure to elevated α-synuclein levels and worse pathology in a mouse model, while human ...
ABCA1 cholesterol trafficking implicated in Parkinson’s neurodegeneration in mice
Human postmortem tissue, cultured cells and mouse experiments implicated abnormal ABCA1-dependent cholesterol trafficking in Parkinson’s-related neurodegeneration.
α-Synuclein Links Parkinson’s and Depression Pathways
In a groundbreaking exploration of neurodegenerative and psychiatric intersections, recent research has illuminated the pivotal role of α-synuclein (α-syn) as ...
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