Mitochondrial Mechanisms Regulate Antitumour Immunity and Reveal Potential Cancer Therapies
A review in Clinical and Experimental Medicine examines how mitochondrial metabolism and signalling govern tumour immune evasion and highlight potential ...
Tag: Warburg Effect
Review Confirms Safety of Hyperbaric Oxygen Therapy Across Human Cancer Cohorts
A comprehensive review synthesizes decades of clinical trials and mechanistic research to demonstrate that hyperbaric oxygen therapy does not accelerate ...
Study reveals how VAV2 fuels glycolysis in esophageal squamous cell carcinoma
A new study reports that the signaling protein VAV2 promotes glycolytic reprogramming and tumor growth in esophageal squamous cell carcinoma ...
Silencing HIF-1α Makes Erlotinib Work Better Against Lung Cancer Cells
A new cell-line study reports that silencing HIF-1α with siRNA synergizes with erlotinib to suppress proliferation, invasion and glycolysis in ...
Hexokinase 2 drives colorectal cancer malignancy by triggering ZNF366 protein degradation
A new study reports that hexokinase 2 promotes malignant phenotypes in colorectal cancer by enhancing UBE3A-dependent ubiquitination and degradation of ...
Metabolic Rewiring Emerges as a Central Driver of Liver Cancer Growth and Treatment Resistance
A new review argues that glucose, lipid, and amino acid metabolism form one interconnected network driving hepatocellular carcinoma growth, immune ...
Research report: Hypoxia-induced GP73 promotes the Warburg effect in hepatocellular carcinoma via HIF-1α
A cell and patient-cohort study links hypoxia-induced GP73 to HIF-1α-dependent glycolysis, growth, invasion and markers of transarterial chemoembolization resistance in ...
Synthetic enzyme redirects metabolism and slows melanoma xenografts
A synthetic enzyme produced pyruvate inside cancer-cell mitochondria, increased oxidative metabolism, altered growth-related gene expression and slowed human melanoma xenografts ...
Epigenetics and Metabolism: The Two-Way Conversation Driving Liver Cancer
A new review in the Chinese Medical Journal maps how epigenetic modifications and metabolic reprogramming fuel each other in hepatocellular ...
Cancer Cells Run on a Metabolic Hybrid Engine, and Surgeons May Soon Map It
A new review argues that cancer cells toggle between glycolysis and mitochondrial respiration in hybrid metabolic states, and that mapping ...
Lactate Marks on Histones Drive Wilms Tumor Growth Through a Self-Reinforcing Genetic Loop
New research reveals that lactate-driven histone H3K18 lactylation activates a PSRC1/AKT/HIF-1α positive feedback loop that propels the malignant progression of ...
Long Noncoding RNA SNHG15 Rewires Liver Cancer Metabolism Through a PDK1-PDHE1α Phosphorylation Switch
A new study shows that the long noncoding RNA SNHG15 drives hepatocellular carcinoma progression by scaffolding the PGK1-PDK1-PDHE1α phosphorylation axis ...
Tumors Steal Fuel and Fuel Inflammation to Starve Head and Neck Cancer Patients
A new review argues that malnutrition in head and neck cancer is driven by tumor metabolism and chronic inflammation rather ...
Hexokinase Release Sparks Warburg Effect, Boosts ATP
In a groundbreaking study that challenges long-standing assumptions about cancer metabolism, researchers have uncovered a crucial link between the spatial ...
Mapping Breast Cancer Metabolism: Paving the Way for Innovative Targeted Therapies
Breast cancer continues to stand as one of the most formidable health challenges facing women globally. Despite advances in detection ...
Scientists Block Newly Discovered Cancer Cell Energy Pathway Using Natural Compound
In a groundbreaking study conducted by researchers at Osaka Metropolitan University, ethyl p-methoxycinnamate (EMC), a predominant compound found in kencur ...
