KLHL6 protein drives colorectal cancer liver spread via MBD2 degradation
A study in the Journal of Experimental & Clinical Cancer Research identifies KLHL6 as a driver of colorectal cancer liver ...
Tag: ubiquitin-proteasome system
Review Explores How Integrated Protein and Organelle Degradation Systems Impact Disease
A review examines how the ubiquitin–proteasome system and autophagy coordinate to eliminate damaged cellular components and prevent disease.
Smurf1 Knockdown Drives Liver Failure via Ferroptosis
A new study reveals that knocking down the protein Smurf1 promotes ferroptosis in acute liver failure by stabilizing Ulk1 and ...
Cell-Penetrating TRIM21 Degrader Destroys Pan-PIM Kinases in Breast Cancer Cells
Researchers have engineered a cell-penetrating TRIM21-based protein degrader that targets all three PIM kinase isoforms to induce apoptosis in breast ...
Protein neddylation: substrate landscape and target modulators
A review maps the neddylation pathway, its non-Cullin substrates and small-molecule inhibitors, including two NAE inhibitors that have entered clinical ...
Alzheimer’s Breakthrough Clue: How the Cell’s Waste Disposal System Breaks the Brain’s Amyloid Pump
A new review argues that the ubiquitin-proteasome system degrades P-glycoprotein at the blood-brain barrier, impairing amyloid-beta clearance and offering new ...
How Pancreatic Cancer Cells Survive Detachment: Autophagy Emerges as Key to Spread
Researchers at Lund University have shown that pancreatic cancer cells engineered to survive detachment consistently switch on autophagy and ubiquitin ...
USP7: The Double-Edged Deubiquitinase That Tumors Cannot Live Without
A new review in Cancer Cell International maps how the deubiquitinase USP7 acts as both tumor promoter and suppressor depending ...
How HIV-1’s Vpr Protein Hijacks a Human Degradation Machine to Destroy Diverse Targets
New cryo-EM structures reveal how the HIV-1 protein Vpr reshapes the human CRL4(VprBP) E3 ligase to degrade host substrates of ...
Liver Cancer’s Hidden Brake: How A20 Marks a Key Tumor Protein for Destruction
New research reveals that the ubiquitin-editing enzyme A20 promotes the degradation of the pro-tumor protein osteopontin in hepatocellular carcinoma, offering ...
Lost tumor brake found to rewire liver cancer cell power plants
Researchers report that loss of the tumor suppressor LZTR1 stabilizes mitochondrial transcription factor A, reprogramming liver cancer cells toward complex ...
Hidden Protein Networks Emerge as Central Players in Huntington’s Disease
A new review argues that Huntington's disease is driven by widespread disruptions of interconnected protein networks, pointing to hub proteins ...
Female Mice Pay a Heavier Price: Sex Hormones Speed Retinal Degeneration
New research shows that female mice lacking the protein quality-control gene Herc3 suffer faster retinal thinning, greater inflammatory activation, and ...
VISTA Blockade Enhances Anti-Tumor Immunotherapy
In the evolving landscape of cancer immunotherapy, the quest for novel immune checkpoint targets has never been more urgent. Conventional ...
Nanobody BioPROTAC Targets YAP to Halt Tumors
In a remarkable stride forward in cancer therapeutics, researchers have unveiled a groundbreaking strategy to target and degrade YAP, a ...
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