A literature review in Advanced Cancer Research reveals that a dynamic network of post-translational modifications orchestrates p53 activity, mutant stability, ...
A study shows that the enzyme MGAT3 curtails lung adenocarcinoma malignancy and dampens EGFR/AKT/ERK signaling in cell-line models.
Promoter hypermethylation suppresses the long non-coding RNA HAND2-AS1 in bladder cancer, while experimental restoration inhibits tumor growth and activates interferon-related ...
In an analysis of clinical tissue specimens and cell models, researchers identified that downregulated lncRNA TRHDE-AS1 independently predicts reduced overall ...
Researchers have identified transcription factor RARG as a candidate tumor suppressor whose loss activates PI3K/AKT signaling via PTHLH downregulation in ...
Researchers found that the E3 ubiquitin ligase CBL suppresses non-small cell lung cancer progression by facilitating the ubiquitination and degradation ...
GADD45A downregulation correlates with advanced pathological stage, poor survival, and an exhausted immune microenvironment in hepatocellular carcinoma.
A five-gene machine-learning signature predicts ovarian cancer survival, and the core gene ACSM3 acts as a tumor suppressor by limiting ...
A new study reports that microRNA-124-3p directly targets the AHR gene to activate autophagy, suppressing stomach adenocarcinoma cell growth in ...
Laboratory and mouse experiments show that the underexpressed gene ENDOD1 suppresses colorectal cancer cell proliferation, migration, and invasion partly by ...
Researchers found RPL22 mutations in 42% of undifferentiated/dedifferentiated endometrial carcinoma samples and showed in cell and xenograft models that the ...
Researchers found that the epigenetically silenced gene PRSS33 acts as a tumor suppressor and endogenous inducer of immunogenic cell death ...
New research in Cell & Bioscience shows that the G-protein subunit GNAZ suppresses lung adenocarcinoma by promoting HUWE1-mediated degradation of ...
Researchers report that the adipogenesis-related gene CEBPD is downregulated in breast tumors, serves as an independent prognostic indicator of survival, ...
New research in Cell Division shows that Bcl-2 overexpression promotes survival of cutaneous squamous cell carcinoma cells by altering mitochondria-associated ...
A new study reports that hexokinase 2 promotes malignant phenotypes in colorectal cancer by enhancing UBE3A-dependent ubiquitination and degradation of ...
New preclinical research shows the STAM protein suppresses clear cell renal cell carcinoma by inactivating EGFR and degrading AKT, inducing ...
University of Michigan researchers report that the molecular glue RPT04402 stabilizes the trimeric tumor suppressor PP2A, shrinking KRAS-mutant lung tumors ...
New research shows the HDAC inhibitor givinostat stalls colorectal cancer growth by upregulating miR-1938 to suppress ADAM12, with no systemic ...
UMBC researchers found that ovarian cancer cells depend heavily on the enzyme USP15, and reducing it slows tumor growth, disrupts ...
