Review Proposes Age Decompression Framework for Cancer Risk in Lung Cohorts
A review synthesizing aging biology, geriatric oncology, and public lung adenocarcinoma cohort analyses proposes an age-decompression framework to reposition chronologic ...
Tag: tumor evolution
Tumor cells may revert to stem-like states, review argues
A new review proposes that mature tumor cells can dedifferentiate into cancer stem cells, acting as a non-genetic engine of ...
Cancer’s rogue DNA: how ecDNA reshapes itself to survive treatment
A new review in Cellular Oncology argues that treatment resistance in cancer often stems from selection and remodeling of pre-existing ...
New Algorithm Reconstructs Tumor Cell Family Trees Under a Strict Evolutionary Rule
Researchers have developed Dolphyin, a combinatorial algorithm that infers 1-Dollo phylogenies from single-cell cancer sequencing data and proved that the ...
Colorectal cancer peritoneal metastases often arise early and polyclonally, sequencing study finds
Sequencing of 11 colorectal cancer patients shows peritoneal metastases often arise early, polyclonally, and through metastasis-to-metastasis seeding.
Rapid autopsy maps lethal bladder cancer evolution in 20 patients
A rapid-autopsy study of 104 tumors from 20 patients found that metastatic bladder tumors appeared to seed further spread and ...
AI could clarify molecular diversity in ovarian cancer liver metastases
A Mini Review finds that AI-assisted integration of genomic and spatial data may reveal lesion-specific biology in ovarian cancer liver ...
Cancer’s resistance may be written years before treatment begins, new hypothesis argues
A new hypothesis proposes that chronic metabolic dysregulation epigenetically primes apoptosis-resistant cancer clones years before diagnosis, reframing treatment resistance as ...
Trapping rogue DNA rings in micronuclei could disarm aggressive tumors
An international research team has shown that rings of extrachromosomal DNA lose their cancer-driving activity when trapped in micronuclei, a ...
Single-cell map shows how pancreatic cancer clones evolve to outsmart treatment
A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...
Single-cell atlas reveals how hidden clones drive pancreatic cancer’s deadly evolution
A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...
Cancer’s Rogue DNA Can Backfire, Trapping Oncogenes in Micronuclei and Slowing Tumors
New research shows that damaged extrachromosomal DNA is trapped in transcriptionally silent micronuclei, impairing cancer cell fitness and predicting better ...
NIH Pioneer Award Backs Scientist Building Cancer Therapies That Evolve Alongside Tumors
NIH has awarded its Director's Pioneer Award to Sylvester Comprehensive Cancer Center virologist Leor Weinberger for developing an evolving oncolytic ...
Genome Instability: Interplay with Immune Response
In recent years, the intersection of genomic instability and immune response has emerged as a compelling area of study, shedding ...
Beyond BRCA: Decoding High-Grade Serous Ovarian Cancer
In the ongoing quest to understand the complexities of ovarian cancer, a groundbreaking study co-authored by Pokorna, Orlickova, Machackova, and ...
Tracking Cancer Drug Resistance Using Genetic Barcoding
In the relentless battle against cancer, understanding how tumors evolve to resist treatment remains one of the most formidable challenges ...
POPULAR NEWS
-
Nursing Student Needlestick Reporting Relies on Supervisor Support Rather Than Systems
-
Cross-Sectional Model Identifies Musculoskeletal Injury Risk in Clinical Nurses
-
Biologging Devices Yield Minimal Short-Term Effects on Three European Toad Species
-
Machine Learning Framework Optimizes Seismic Retrofitting for Aging Railway Viaduct Columns