Tag: targeted therapy

A 13-year Polish study of 219 acute myeloid leukemia patients shows that stopping fluoroquinolone prophylaxis in 2018 was clinically safe, ...

A new meta-analysis of 11 randomized trials shows dupilumab and nemolizumab deliver robust itch and lesion relief in prurigo nodularis, ...

A comprehensive review highlights how copper nanoparticles combine drug delivery, targeted tumor therapy, and the newly discovered cell death pathway ...

A Thai prospective study used plasma-based 52-gene sequencing to map how T790M-positive lung cancers resist osimertinib, finding heterogeneous resistance mutations ...

A CT-based multimodal radiogenomic model combining tumor imaging, perirenal fat features, and genetic data outperformed conventional risk stratification for clear ...

A comprehensive epigenetic analysis led by St. Jude and KiTZ identified the chromatin regulator KDM2B as an essential, selective dependency ...

A comprehensive Chinese Medical Journal review led by Professor Feng Wang synthesizes five years of advances in esophageal cancer, highlighting ...

A new review highlights how chitosan-based nanoparticles can deliver drugs precisely, overcome chemoresistance, and combine photothermal, photodynamic, and immunotherapeutic strategies ...

A new review in Cancer Cell International maps how the deubiquitinase USP7 acts as both tumor promoter and suppressor depending ...

A new review maps the molecular drivers of pituitary neuroendocrine tumors, evaluates established and emerging drug therapies, and separates clinically ...

A sweeping review in the Journal of Advanced Research details how hydrogels, lipid nanoparticles, polymers, and biomimetic carriers are overcoming ...

A multicenter real-world study found that first-line trastuzumab deruxtecan doubled progression-free survival compared with chemotherapy in HER2-altered advanced NSCLC, while ...

A first-in-human trial shows that the conformation-selective PI3Kδ inhibitor roginolisib is well tolerated in advanced cancers and is associated with ...

A novel CDH17-targeted antibody-drug conjugate called SCR-A008 achieved sustained tumor inhibition in gastric cancer PDX models, with a paclitaxel combination ...

A multicenter study shows that a hybrid model combining MRI radiomics, delta features, and clinical variables predicts overall survival in ...

A new review in the Journal of Translational Medicine details how RGS proteins, the off switches of GPCR signaling, reshape ...

A new review argues that glioblastoma evades EGFR-targeted therapies through compensatory STAT3 activation, positioning the EGFR–STAT3 axis as an adaptive ...

A new review argues that dry eye disease is sustained by a self-amplifying inflammatory circuit linking the corneal epithelium, immune ...

A new preclinical study shows that the β-catenin/CBP inhibitor ICG-001 selectively kills endometrial cancer cells carrying both PIK3CA and CTNNB1 ...

A 563-patient genomic study from Peking University reveals how KMT2C/D loss-of-function alterations define a hypermutated, MSI-high subgroup of gastric cancer ...