Astrocytic Stat3 Proves Dispensable for Prion Disease Progression in Mice
A study in mice reveals that deleting Stat3 in activated astrocytes dampens specific inflammatory transcripts without altering prion disease progression ...
Tag: STAT3 Signaling
Claudin-8 Protects Against Colitis-Associated Colorectal Cancer by Preserving Intestinal Barrier Homeostasis
A study in patient tissues and mouse models shows Claudin-8 deficiency promotes colitis-associated colorectal cancer by impairing intestinal barrier integrity ...
Bruceine D suppresses osteoclast formation and protects bone in ovariectomized mice
A preclinical cell-and-mouse study found that Bruceine D inhibited osteoclast formation through effects involving STAT3, NF-κB and NFATc1 while improving ...
Diabetes drug target PPARγ rejuvenates aging ovaries in mice
Activating the nuclear receptor PPARγ with rosiglitazone raised AMH signaling and improved follicle numbers, oocyte quality, and blastocyst development in ...
Lactate-Driven Epigenetic Shifts Reshape Liver Cancer Immunity
New research reveals that lactate-driven histone lactylation promotes Treg/Th17 imbalance in liver cancer via the PTPRM-STAT3 axis.
Hidden Switch Lets Melanoma Cells Flip Into Metastasis Mode, Study Finds
Researchers in Milan have identified MyD88 as a tumor cell-intrinsic switch that sustains a metastasis-competent, integrin-driven cell state in NRAS-mutant ...
Microglial CX3CR1 Deficiency Alters Cone Photoreceptor Vulnerability
In a groundbreaking discovery that promises to illuminate the complex interplay between the immune system and neuronal health, researchers have ...
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