Gut bacteria shift in lung cancer patients before and after radiotherapy
A small study found distinct gut microbiota profiles in small cell lung cancer patients, with reduced beneficial bacteria and increased ...
Tag: small-cell lung cancer
CRISPR Screen Points to Autophagy Blockade Plus PARP Inhibitor Against Lung Cancer
A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and ...
MRI Surveillance Alone Beats Preventive Brain Radiation in Small-Cell Lung Cancer Trial
The phase III MAVERICK trial found that brain MRI surveillance without prophylactic cranial irradiation improved cognitive failure-free survival and caused ...
Research report: Neurological syndrome with CSF anti-Hu positivity during serplulimab therapy in extensive-stage small-cell lung cancer: a case report
A case report describes a woman with extensive-stage small-cell lung cancer who developed a cerebrospinal fluid anti-Hu-positive neurological syndrome during ...
Tarlatamab plus durvalumab extends survival in first-line maintenance for extensive-stage small cell lung cancer
Phase 3 DeLLphi-305 results show that adding tarlatamab to durvalumab as first-line maintenance therapy extended median overall survival by more ...
Thoracic radiotherapy faces a consolidation paradox in small cell lung cancer
A narrative review finds no support for routine thoracic radiotherapy in chemo-immunotherapy-treated extensive-stage small cell lung cancer and highlights unresolved ...
Antibody-Drug Conjugate Cuts Death Risk by 54% in Relapsed Small-Cell Lung Cancer
The phase III TAISHAN-302 trial found that the anti-B7-H3 antibody-drug conjugate Tam-Peli reduced the risk of death by 54 percent ...
Cysteine Dependence Reveals Metabolic Weakness in Small Cell Lung Cancer
Researchers at the University of Cologne have identified a shared metabolic vulnerability in small cell lung cancer, where all cell ...
CT and biomarkers support small cell lung cancer diagnosis in unbiopsied patient
A two-case report found that characteristic CT findings, markedly elevated NSE and multidisciplinary review enabled an image-supported small cell lung ...
MRI surveillance improved cognition in small-cell lung cancer trial
A randomized phase III trial found better cognitive failure–free survival with brain MRI surveillance alone than with surveillance plus cranial ...
Dana-Farber to Present Phase 3 Lung Cancer Data at ESMO
Dana-Farber will present the phase 3 DeLLphi-305 primary analysis in extensive-stage small cell lung cancer at the 2026 ESMO Presidential ...
Hungary’s Decade of Data Reveals the Harsh Reality of Extensive-Stage Small Cell Lung Cancer
A nationwide analysis of 8,104 Hungarian patients treated from 2013 to 2022 shows median survival of just 9.3 months with ...
Hidden Immune Cells Offer New Hope Against the Deadliest Lung Cancer
WEHI researchers have discovered that gamma delta T cells can recognise and kill small cell lung cancer, and that two ...
Chronic Stress Burden and Genes Together Shape Lung Cancer Risk, Study Finds
A prospective study of over 336,000 UK Biobank participants links high allostatic load to elevated lung cancer risk, especially small-cell ...
Focused radiosurgery doubles survival in lung cancer that spreads to the brain
A randomized phase 3 trial found that patients with small cell lung cancer and brain metastases lived a median of ...
Radiosurgery Boosts Survival in Small Cell Lung Cancer Brain Metastases Without Cognitive Trade-Off
A Phase III NRG Oncology trial found that stereotactic radiosurgery did not improve neurocognitive outcomes over hippocampal-avoidant whole-brain radiotherapy but ...
PARP Inhibitor Plus Temozolomide Shows Promise in Relapsed Small-Cell Lung Cancer Trial
A phase Ib/II trial in China found that the oral PARP inhibitor HTMC0435 combined with temozolomide produced a manageable safety ...
Two-Thirds of Eligible Lung Cancer Patients Miss Guideline-Backed Infection Shield, French Data Show
A nationwide analysis of French hospital cohorts finds that only about two-thirds of small-cell lung cancer patients eligible for G-CSF ...
AI Reads Chest Scans to Predict Lung Cancer Type When Brain Metastases Strike First
Machine-learning models combining clinical data and chest CT report features can probabilistically classify lung cancer subtypes in patients presenting with ...
HDAC6 Drives Metastasis and Immunosuppression in Lung Cancer
In the realm of oncological research, the intricate mechanisms behind cancer metastasis and immune evasion are crucial questions that scientists ...
