Tag: Single-nucleus RNA sequencing

UCLA researchers identified a GGPP-Rho-YAP signaling pathway in hepatic stellate cells around MASLD-related liver tumors that statins suppressed in laboratory ...

Researchers have identified a previously unrecognized pineal gland tumor type, provisionally named PINNED, defined by a unique DNA methylation signature ...

An AI-driven single-cell and spatial multi-omics study defines three glioma ecosystem states and shows that a hypoxic myeloid-mesenchymal state independently ...

Single-nucleus RNA sequencing of postmortem brains reveals that carriers of the rare MAPT A152T variant show distinct cell type-specific gene-expression ...

A fibril-selective, Fc-free nanantibody bound Alzheimer’s-associated amyloid assemblies and reduced injury signals in human neurons and forebrain organoids, while remaining ...

A computational framework linked spatial gene-expression gradients to net-production direction under steady-state and positive-flow assumptions, with reproducible directions in human ...

A public-data reanalysis identified broad tumor-normal gene-expression changes in sinonasal squamous cell carcinoma and nominated four preliminary candidate biomarkers supported ...

A reanalysis of two public single-nucleus RNA-sequencing cohorts identifies a MEOX1-positive, FAP-positive, relatively ACTA2-low fibroblast state that is reproducibly enriched ...

Researchers have built a single-nucleus transcriptomic atlas of the developing human inner ear, revealing that Hedgehog signaling repression is required ...

A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...

New research shows that the Alzheimer's risk gene BIN1 acts as a brake on microglial inflammation, and its loss exaggerates ...

Researchers combined single nucleus RNA-sequencing with GWAS and UK Biobank data to show that an obesity-linked variant in SREBF1 allele-specifically ...

A multi-platform transcriptomic atlas of the human right ventricle reveals a two-phase progression to failure, with early erosion of protective ...

New research reveals that high-frequency transcranial magnetic stimulation restores motor function and relieves neuropathic pain after spinal cord injury by ...

A new single-cell and animal study links SLC7A11-high astrocyte states to antioxidant failure and synaptic remodeling in multiple sclerosis, pointing ...

A phase-2 randomized trial shows intermittent dasatinib plus quercetin significantly improved liver fibrosis and resolved MASH in nearly half of ...

A comprehensive review reveals that single-cell sequencing of the dorsal root ganglion shows neuropathic pain is not one disease but ...

A single-cell atlas of 554 human cataract capsules reveals that nerve-like fibers invade the aging lens through an NRG1-ERBB3 signaling ...

Single-nucleus RNA sequencing of the mouse brain reveals that basal forebrain cholinergic neurons undergo uniquely damaging stress-related transcriptional changes with ...

Groundbreaking Study Uses Single-Nucleus RNA Sequencing to Unravel Brown/Beige Adipose Tissue Dynamics Post-Bariatric Surgery In a remarkable advancement within the ...