A large single-nucleus RNA sequencing study revealed that colorectal tumors in younger patients possess higher proportions of supporting cells, elevated ...
A single-nucleus sequencing study published in Nature Medicine identified distinct cellular compositions, non-coding RNA activity, and tissue-invasion signaling pathways in ...
Reanalysis of mouse transcriptomic data identifies Lpl as an anti-inflammatory gene linking lipid metabolism to kidney injury in diabetes and ...
Researchers mapped Alzheimer's disease heterogeneity across bulk, single-nucleus, and spatial transcriptomics using a neural pathway unsupervised learning framework.
A large prospective study identified prediagnostic plasma proteomic patterns and highlighted NECTIN2 as a key candidate in age-related macular degeneration.
Researchers have introduced SWANS, a configurable analysis pipeline that evaluates multiple methods and parameters in a single run for single-cell ...
A multicenter single-cell transcriptomic atlas of non-small-cell lung cancer identifies distinct malignant cell states and microenvironmental interactions that drive metastatic ...
Single-cell and single-nucleus transcriptomic analyses across fruit fly, mouse, and stem cell models reveal early cell-type-specific drivers of amyotrophic lateral ...
Researchers integrated multi-omics analyses and cellular assays to demonstrate that sinomenine modulates PCK1-associated immunometabolic pathways and attenuates inflammatory stress in ...
Spatial and single-nucleus sequencing in aging mice reveals that inflammatory and fibrotic cellular remodeling concentrates primarily within the aortic root ...
A new multi-omic study identifies CR1-positive oligodendrocytes as a key pathological feature in Alzheimer's disease, with peripheral blood CR1 levels ...
A multi-cohort study of donor brain tissue shows that molecular sex differences in the Alzheimer's cortex represent stable offsets that ...
A multi-omics study in mice shows that the four-herb Qi-Blood Harmony Formula protects the post-infarction heart by restoring energy metabolism ...
Integrated single-nucleus and spatial transcriptomics of 43 choroid plexus tumours reveal ten tumour metaprograms that cluster by methylation subtype and ...
Breast tumors with high intratumoral androstenedione show gene activity linked to lower proliferation, earlier stage and better survival, while low ...
Single-nucleus RNA sequencing shows that Cd47 loss shifts the mouse hippocampal transcriptome toward a state resembling mild excitotoxic stress.
A mouse study finds that glutamatergic and GABAergic neurons in the dorsomedial hypothalamus regulate post-anesthesia sleep disturbance through distinct CB1 ...
Single-cell transcriptomic analysis shows tree shrew sperm development resembles human and macaque patterns more closely than the mouse does.
A new study links upregulated Src kinase and the transcription factor NEUROD2 to early tau pathology in Alzheimer's disease, supported ...
A single-nucleus atlas of human visceral fat identifies THBS1-expressing stem cells and adipocytes as drivers of fibro-inflammatory remodeling in obesity ...
