Review Explores Role of Somatic Mutations in Neurodegenerative Disease Mechanisms
A review in BMC Biology examines how advanced sequencing and computational tools detect ultra-rare somatic mutations and investigate their causal ...
Tag: single-cell sequencing
Scientists map a million cells revealing the predictable rules of glioblastoma
A single-cell and spatial atlas of 12 glioblastoma tumours shows that cancer cells progress through the same ordered sequence of ...
ZG16 Overexpression Curbs Colorectal Cancer Cell Growth and Boosts Macrophage Phagocytosis in Lab Tests
ZG16 overexpression in SW620 colorectal cancer cells suppressed proliferation, migration and invasion, induced apoptosis, reduced CD47 and CD24 expression, and ...
AI in Triple Negative Breast Cancer Research Surges, Ten-Year Mapping Shows
A ten-year bibliometric analysis of 320 articles finds artificial intelligence research on triple negative breast cancer peaked at 104 publications ...
Fibroblasts That Show Tumors’ IDs May Be Shapeshifters, Not Fixed Subtypes
A new perspective argues that antigen-presenting fibroblasts in gastrointestinal tumors are reversible states whose immune role depends on unmeasured co-stimulatory ...
New Algorithm Reconstructs Tumor Cell Family Trees Under a Strict Evolutionary Rule
Researchers have developed Dolphyin, a combinatorial algorithm that infers 1-Dollo phylogenies from single-cell cancer sequencing data and proved that the ...
Bibliometric Analysis Maps a Decade of MDSC Research in the Tumor Microenvironment
A bibliometric analysis of 5,967 publications maps a decade of MDSC research, identifying leading countries, institutions, authors, and emerging research ...
S100P Emerges as a Prognostic and Immune-Linked Biomarker in Lung Adenocarcinoma
A bioinformatics and single-cell study finds that S100P is elevated in lung adenocarcinoma, tracks with advanced stage and poorer survival, ...
Hidden immune activity may explain colorectal cancer risk in PSC
An observational study found hidden immune activity and a distinctive gut environment in bowel disease associated with PSC, offering a ...
Cohesin Loops, Baciptosis, Microexons: MSK Studies Illuminate Gene Control and Immunity
New research from Memorial Sloan Kettering Cancer Center reveals how cohesin activates distant genes, identifies an immunogenic cell death called ...
Persister cells hiding in minimal residual disease drive cancer relapse
A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...
Scientists Map Two Distinct T Cell Exhaustion Programs Driving AML Relapse Before and After Transplant
Single-cell sequencing reveals that self-derived and donor-derived exhausted T cells in acute myeloid leukemia run on different transcriptional programs, with ...
Dual autoencoder framework sharpens single-cell clustering accuracy
A new deep clustering method, scDAEC, combines two autoencoders and multi-head attention to untangle noisy single-cell RNA sequencing data, outperforming ...
Scientists Uncover Four Genes That May Explain Why Psoriasis and Depression Strike Together
An integrated multi-omics study identifies four shared genes and folic acid as a potential therapeutic link between psoriasis and depression.
Genomic Imprinting’s Hidden Role in Cancer: New Methods Tackle Loss of Imprinting
A new review highlights how loss of imprinting drives tumour growth and why emerging single-cell, spatial, and long-read methods may ...
Scientists uncover how tobacco rewires head and neck cancer metabolism through a single mucin molecule
New research reveals that tobacco carcinogens lift a GATA4-mediated brake on the mucin MUC5B, driving fatty acid metabolism and immune ...
Single-Cell Sequencing Reveals Mitochondrial DNA Damage in Vulnerable Parkinson’s Neurons
For the first time, researchers have sequenced mitochondrial DNA from individual vulnerable brainstem neurons in Parkinson's disease, revealing extensive deletions ...
Tumors Are Not Sterile: How Microbes Living Inside Cancers Reshape Immunity and Immunotherapy
A new review in Molecular Cancer argues that microbes living inside tumors dynamically reprogram immunity and can determine whether patients ...
Blood Test Clue: Immune Cells That Betray Early Lung Cancer Before It Strikes
Researchers have discovered a clonally coordinated network of suppressive regulatory T cells that spans the blood, lymph nodes and airways ...
Cellular family trees: scientists map how one cell builds an entire mouse
Two independent HHMI teams have used DNA recording technologies to reconstruct the most complete cellular family trees ever made for ...
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